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Effect of female genital schistosomiasis and anti-schistosomal treatment on monocytes, CD4+ T-cells and CCR5 expression in the female genital tract

PloS one, 2014-06, Vol.9 (6), p.e98593-e98593 [Peer Reviewed Journal]

2014 Kleppa et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;info:eu-repo/semantics/openAccess ;2014 Kleppa et al 2014 Kleppa et al ;ISSN: 1932-6203 ;EISSN: 1932-6203 ;DOI: 10.1371/journal.pone.0098593 ;PMID: 24896815

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Title:
Effect of female genital schistosomiasis and anti-schistosomal treatment on monocytes, CD4+ T-cells and CCR5 expression in the female genital tract
Author: Kleppa, Elisabeth ; Ramsuran, Veron ; Zulu, Siphosenkosi ; Karlsen, Gunn Hege ; Bere, Alfred ; Passmore, Jo-Ann S ; Ndhlovu, Patricia ; Lillebø, Kristine ; Holmen, Sigve D ; Onsrud, Mathias ; Gundersen, Svein Gunnar ; Taylor, Myra ; Kjetland, Eyrun F ; Ndung'u, Thumbi
LUTY, Adrian J. F.
Subjects: Acquired immune deficiency syndrome ; Adolescent ; Adult ; AIDS ; Animals ; Antiretroviral drugs ; Biology and Life Sciences ; Blood ; Case-Control Studies ; CCR5 protein ; CD14 antigen ; CD4 antigen ; CD4-Positive T-Lymphocytes - drug effects ; CD4-Positive T-Lymphocytes - immunology ; CD4-Positive T-Lymphocytes - metabolism ; Cell density ; Chemokines ; Coinfection ; Compartments ; Cytometry ; Disease transmission ; Epidemiology ; Female ; Females ; Flow cytometry ; Gene Expression ; Genital Diseases, Female - drug therapy ; Genital Diseases, Female - immunology ; Genital Diseases, Female - metabolism ; Genital Diseases, Female - parasitology ; Genital tract ; Genitalia, Female - immunology ; Genitalia, Female - metabolism ; Genitalia, Female - parasitology ; Health care ; Health risks ; HIV ; Hospitals ; Human immunodeficiency virus ; Humans ; Immunophenotyping ; Infections ; Infectious diseases ; Lesions ; Lymphocytes T ; Medicine ; Medicine and Health Sciences ; Microscopy ; Monocytes ; Monocytes - drug effects ; Monocytes - immunology ; Monocytes - metabolism ; Mucosa ; Ova ; Parasitic diseases ; Pathogenesis ; Phenotype ; Polymerase chain reaction ; Population studies ; Populations ; Praziquantel - pharmacology ; Praziquantel - therapeutic use ; Public health ; Receptors, CCR5 - genetics ; Receptors, CCR5 - metabolism ; Schistosoma haematobium ; Schistosoma mansoni ; Schistosomiasis ; Schistosomiasis - drug therapy ; Schistosomiasis - immunology ; Schistosomiasis - metabolism ; Schistosomiasis - parasitology ; Studies ; Trends ; Tropical diseases ; Urine ; Womens health ; Young Adult
Is Part Of: PloS one, 2014-06, Vol.9 (6), p.e98593-e98593
Description: Schistosoma haematobium is a waterborne parasite that may cause female genital schistosomiasis (FGS), characterized by genital mucosal lesions. There is clinical and epidemiological evidence for a relationship between FGS and HIV. We investigated the impact of FGS on HIV target cell density and expression of the HIV co-receptor CCR5 in blood and cervical cytobrush samples. Furthermore we evaluated the effect of anti-schistosomal treatment on these cell populations. The study followed a case-control design with post treatment follow-up, nested in an on-going field study on FGS. Blood and cervical cytobrush samples were collected from FGS negative and positive women for flow cytometry analyses. Urine samples were investigated for schistosome ova by microscopy and polymerase chain reaction (PCR). FGS was associated with a higher frequency of CD14+ cells (monocytes) in blood (11.5% in FGS+ vs. 2.2% in FGS-, p = 0.042). Frequencies of CD4+ cells expressing CCR5 were higher in blood samples from FGS+ than from FGS- women (4.7% vs. 1.5%, p = 0.018). The CD14+ cell population decreased significantly in both compartments after anti-schistosomal treatment (p = 0.043). Although the frequency of CD4+ cells did not change after treatment, frequencies of CCR5 expression by CD4+ cells decreased significantly in both compartments (from 3.4% to 0.5% in blood, p = 0.036; and from 42.4% to 5.6% in genital samples, p = 0.025). The results support the hypothesis that FGS may increase the risk of HIV acquisition, not only through damage of the mucosal epithelial barrier, but also by affecting HIV target cell populations, and that anti-schistosomal treatment can modify this.
Publisher: United States: Public Library of Science
Language: English
Identifier: ISSN: 1932-6203
EISSN: 1932-6203
DOI: 10.1371/journal.pone.0098593
PMID: 24896815
Source: DOAJ Directory of Open Access Journals
GFMER Free Medical Journals
MEDLINE
NORA Norwegian Open Research Archives
PubMed Central
Public Library of Science (PLoS)
ProQuest Central

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Effect of female genital schistosomiasis and anti-schistosomal treatment on monocytes, CD4+ T-cells and CCR5 expression in the female genital tract

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