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1-Hydroxypyrene concentrations in first morning voids and 24-h composite urine: intra- and inter-individual comparisons

Journal of exposure science & environmental epidemiology, 2008-09, Vol.18 (5), p.477-485 [Peer Reviewed Journal]

COPYRIGHT 2008 Nature Publishing Group ;Copyright Nature Publishing Group Sep 2008 ;Nature Publishing Group 2008. ;ISSN: 1559-0631 ;EISSN: 1559-064X ;DOI: 10.1038/sj.jes.7500639 ;PMID: 18059422

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Title:
1-Hydroxypyrene concentrations in first morning voids and 24-h composite urine: intra- and inter-individual comparisons
Author: Han, In-Kyu ; Duan, Xiaoli ; Zhang, Lin ; Yang, Hongbiao ; Rhoads, George G ; Wei, Fusheng ; Zhang, Junfeng
Subjects: 1-Hydroxypyrene ; Adult ; Benzopyrenes - analysis ; Biomarkers ; Biomarkers - urine ; China ; Coke ; Coke ovens ; Creatinine ; Creatinine - urine ; Environmental Monitoring ; Exposure ; Female ; Humans ; Indexing in process ; Industry ; Interviews as Topic ; Linear Models ; Male ; Middle Aged ; Occupational exposure ; Occupational Exposure - analysis ; Occupations - classification ; Polycyclic aromatic hydrocarbons ; Polycyclic Aromatic Hydrocarbons - urine ; Pyrenes - analysis ; Pyrenes - metabolism ; Q1 ; Seasons ; Time Factors ; Urine ; Urine - chemistry ; Voids ; Working conditions
Is Part Of: Journal of exposure science & environmental epidemiology, 2008-09, Vol.18 (5), p.477-485
Description: Urinary 1-hydroxypyrene (1-OHP) has been suggested as an exposure biomarker for polycyclic aromatic hydrocarbons (PAHs). However, it remains unknown whether a first morning urine sample can be used to reflect average exposure. In this paper, we examine intra-individual differences and inter-individual associations between first morning voids and 24-h composite urine samples. The analysis was performed using data collected from 100 adults who had a wide range of PAH exposure due to differences in their occupation, e.g., coke oven workers vs. non-coke oven workers. For each subject, all the urine voids within each of two 24-h measurement periods were collected. Results showed a significant (40% to 62%) intra-individual difference between first morning voids and 24-h urinary 1-OHP concentrations (in ng/ml urine). Creatinine adjustments of 1-OHP concentrations (in micromol/mol urinary creatinine) reduced the intra-individual difference by approximately 10%. Across all the subjects, a high overall correlation (r=0.76) was observed between first morning and 24-h average 1-OHP concentrations. Work environment and sampling season were found to significantly affect the relationship between first morning and 24-h 1-OHP concentrations. An increase of 1 ng/ml of first morning urinary 1-OHP predicted an increase of 0.5 and 0.25 ng/ml of 24-h urinary 1-OHP for coke oven workers and non-coke oven workers, respectively. Data collected in a winter season showed a higher correlation between first morning and 24-h concentrations than data collected in a fall season. Creatinine adjustments did not significantly improve overall correlations between first morning void and 24-h measurements, but increased total variances for 24-h urines explained by first morning urines in coke workers.
Publisher: United States: Nature Publishing Group
Language: English
Identifier: ISSN: 1559-0631
EISSN: 1559-064X
DOI: 10.1038/sj.jes.7500639
PMID: 18059422
Source: AUTh Library subscriptions: ProQuest Central
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1-Hydroxypyrene concentrations in first morning voids and 24-h composite urine: intra- and inter-individual comparisons

COPYRIGHT 2008 Nature Publishing Group ;Copyright Nature Publishing Group Sep 2008 ;Nature Publishing Group 2008. ;ISSN: 1559-0631 ;EISSN: 1559-064X ;DOI: 10.1038/sj.jes.7500639 ;PMID: 18059422

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