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Rationale and study design of the Japan environment and children's study (JECS)

BMC public health, 2014-01, Vol.14 (1), p.25-25, Article 25 [Peer Reviewed Journal]

COPYRIGHT 2014 BioMed Central Ltd. ;Copyright © 2014 Kawamoto et al.; licensee BioMed Central Ltd. 2014 Kawamoto et al.; licensee BioMed Central Ltd. ;ISSN: 1471-2458 ;EISSN: 1471-2458 ;DOI: 10.1186/1471-2458-14-25 ;PMID: 24410977

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Title:
Rationale and study design of the Japan environment and children's study (JECS)
Author: Kawamoto, Toshihiro ; Nitta, Hiroshi ; Murata, Katsuyuki ; Toda, Eisaku ; Tsukamoto, Naoya ; Hasegawa, Manabu ; Yamagata, Zentaro ; Kayama, Fujio ; Kishi, Reiko ; Ohya, Yukihiro ; Saito, Hirohisa ; Sago, Haruhiko ; Okuyama, Makiko ; Ogata, Tsutomu ; Yokoya, Susumu ; Koresawa, Yuji ; Shibata, Yasuyuki ; Nakayama, Shoji ; Michikawa, Takehiro ; Takeuchi, Ayano ; Satoh, Hiroshi
Subjects: Adolescent ; Adult ; Air quality ; Analysis ; Biomarkers - blood ; Biomarkers - metabolism ; Biomarkers - urine ; Child ; Child Welfare ; Child, Preschool ; Cohort Studies ; Computer Simulation ; Environment ; Environmental Exposure - adverse effects ; Environmental Exposure - analysis ; Environmental Pollutants - adverse effects ; Environmental Pollutants - metabolism ; Family Characteristics ; Female ; Fetal Blood - chemistry ; Hair - chemistry ; Humans ; Infant ; Infant, Newborn ; Japan ; Longitudinal Studies ; Male ; Management science ; Maternal Exposure - adverse effects ; Milk, Human - chemistry ; Nervous system diseases ; Pregnancy ; Pregnancy Complications - chemically induced ; Research Design ; Social aspects ; Study Protocol
Is Part Of: BMC public health, 2014-01, Vol.14 (1), p.25-25, Article 25
Description: There is global concern over significant threats from a wide variety of environmental hazards to which children face. Large-scale and long-term birth cohort studies are needed for better environmental management based on sound science. The primary objective of the Japan Environment and Children's Study (JECS), a nation-wide birth cohort study that started its recruitment in January 2011, is to elucidate environmental factors that affect children's health and development. Approximately 100,000 expecting mothers who live in designated study areas will be recruited over a 3-year period from January 2011. Participating children will be followed until they reach 13 years of age. Exposure to environmental factors will be assessed by chemical analyses of bio-specimens (blood, cord blood, urine, breast milk, and hair), household environment measurements, and computational simulations using monitoring data (e.g. ambient air quality monitoring) as well as questionnaires. JECS' priority outcomes include reproduction/pregnancy complications, congenital anomalies, neuropsychiatric disorders, immune system disorders, and metabolic/endocrine system disorders. Genetic factors, socioeconomic status, and lifestyle factors will also be examined as covariates and potential confounders. To maximize representativeness, we adopted provider-mediated community-based recruitment. Through JECS, chemical substances to which children are exposed during the fetal stage or early childhood will be identified. The JECS results will be translated to better risk assessment and management to provide healthy environment for next generations.
Publisher: England: BioMed Central Ltd
Language: English
Identifier: ISSN: 1471-2458
EISSN: 1471-2458
DOI: 10.1186/1471-2458-14-25
PMID: 24410977
Source: Geneva Foundation Free Medical Journals at publisher websites
Springer Open Access
MEDLINE
PubMed Central（OA）
ROAD: Directory of Open Access Scholarly Resources
ProQuest Central
DOAJ Directory of Open Access Journals

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Rationale and study design of the Japan environment and children's study (JECS)

COPYRIGHT 2014 BioMed Central Ltd. ;Copyright © 2014 Kawamoto et al.; licensee BioMed Central Ltd. 2014 Kawamoto et al.; licensee BioMed Central Ltd. ;ISSN: 1471-2458 ;EISSN: 1471-2458 ;DOI: 10.1186/1471-2458-14-25 ;PMID: 24410977

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