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Monkeypox

The Lancet (British edition), 2023-01, Vol.401 (10370), p.60-74 [Peer Reviewed Journal]

2023 Elsevier Ltd ;Copyright © 2023 Elsevier Ltd. All rights reserved. ;2023. Elsevier Ltd ;2022 Elsevier Ltd. All rights reserved. 2022 Elsevier Ltd ;ISSN: 0140-6736 ;EISSN: 1474-547X ;DOI: 10.1016/S0140-6736(22)02075-X ;PMID: 36403582

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Title:
Monkeypox
Author: Mitjà, Oriol ; Ogoina, Dimie ; Titanji, Boghuma K ; Galvan, Cristina ; Muyembe, Jean-Jacques ; Marks, Michael ; Orkin, Chloe M
Subjects: Abscesses ; Anorectal ; Antigens ; Antiviral Agents ; Antiviral drugs ; Body fluids ; Complications ; Cowpox ; Deoxyribonucleic acid ; DNA ; Edema ; Epidemics ; Epidemiology ; Exanthema ; Fatalities ; Gays & lesbians ; Gene expression ; Genomes ; Health risks ; Health services ; Homosexuality, Male ; Humans ; Illnesses ; Infections ; Laboratories ; Lymphatic system ; Male ; Medical treatment ; Mens health ; Monkeypox ; Mortality ; Mpox (monkeypox) - diagnosis ; Mpox (monkeypox) - epidemiology ; Mutation ; Myalgia ; Orthopoxvirus ; Outbreaks ; Pain ; Patients ; Penis ; Prophylaxis ; Proteins ; Public health ; Seminar ; Sexual and Gender Minorities ; Smallpox ; Vaccines ; Vaccinia ; Viral infections ; Virology ; Virulence ; Viruses
Is Part Of: The Lancet (British edition), 2023-01, Vol.401 (10370), p.60-74
Description: Monkeypox is a zoonotic illness caused by the monkeypox virus, an Orthopoxvirus in the same genus as the variola, vaccinia, and cowpox viruses. Since the detection of the first human case in the Democratic Republic of the Congo in 1970, the disease has caused sporadic infections and outbreaks, mainly restricted to some countries in west and central Africa. In July, 2022, WHO declared monkeypox a Public Health Emergency of International Concern, on account of the unprecedented global spread of the disease outside previously endemic countries in Africa and the need for global solidarity to address this previously neglected disease. The 2022 outbreak has been primarily associated with close intimate contact (including sexual activity) and most cases have been diagnosed among men who have sex with men, who often present with novel epidemiological and clinical characteristics. In the 2022 outbreak, the incubation period ranges from 7 days to 10 days and most patients present with a systemic illness that includes fever and myalgia and a characteristic rash, with papules that evolve to vesicles, pustules, and crusts in the genital, anal, or oral regions and often involve the mucosa. Complications that require medical treatment (eg, antiviral therapy, antibacterials, and pain control) occur in up to 40% of patients and include rectal pain, odynophagia, penile oedema, and skin and anorectal abscesses. Most patients have a self-limited illness; between 1% and 13% require hospital admission (for treatment or isolation), and the case-fatality rate is less than 0·1%. A diagnosis can be made through the presence of Orthopoxvirus DNA in PCRs from lesion swabs or body fluids. Patients with severe manifestations and people at risk of severe disease (eg, immunosuppressed people) could benefit from antiviral treatment (eg, tecovirimat). The current strategy for post-exposure prophylaxis or pre-exposure prophylaxis for people at high risk is vaccination with the non-replicating modified vaccinia Ankara. Antiviral treatment and vaccines are not yet available in endemic countries in Africa.
Publisher: England: Elsevier Ltd
Language: English
Identifier: ISSN: 0140-6736
EISSN: 1474-547X
DOI: 10.1016/S0140-6736(22)02075-X
PMID: 36403582
Source: ProQuest One Psychology
MEDLINE
ProQuest Central

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Monkeypox

2023 Elsevier Ltd ;Copyright © 2023 Elsevier Ltd. All rights reserved. ;2023. Elsevier Ltd ;2022 Elsevier Ltd. All rights reserved. 2022 Elsevier Ltd ;ISSN: 0140-6736 ;EISSN: 1474-547X ;DOI: 10.1016/S0140-6736(22)02075-X ;PMID: 36403582

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