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The novel regulatory role of lncRNA‐miRNA‐mRNA axis in cardiovascular diseases

Journal of cellular and molecular medicine, 2018-12, Vol.22 (12), p.5768-5775 [Peer Reviewed Journal]

2018 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine. ;ISSN: 1582-1838 ;EISSN: 1582-4934 ;DOI: 10.1111/jcmm.13866 ;PMID: 30188595

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  • Title:
    The novel regulatory role of lncRNA‐miRNA‐mRNA axis in cardiovascular diseases
  • Author: Huang, Ying
  • Subjects: cardiovascular disease ; Cardiovascular Diseases - genetics ; Cardiovascular Diseases - pathology ; Gene Expression Regulation ; Humans ; long noncoding RNA ; microRNA ; MicroRNAs - genetics ; MicroRNAs - metabolism ; mRNA ; Review ; Reviews ; RNA, Long Noncoding - genetics ; RNA, Long Noncoding - metabolism ; RNA, Messenger - genetics ; RNA, Messenger - metabolism
  • Is Part Of: Journal of cellular and molecular medicine, 2018-12, Vol.22 (12), p.5768-5775
  • Description: Long noncoding RNAs (lncRNAs) are RNAs longer than 200 nt in length that are characterized by low levels of sequence conservation and expression; lncRNAs modulate various biological functions at epigenetic, transcriptional and post‐transcriptional levels, or directly regulate protein activity. As a family of small and evolutionarily conserved noncoding RNAs, microRNAs (miRNAs) are capable of regulating physiological and pathological processes via inhibiting target mRNA translation or promoting mRNA degradation. A number of studies have confirmed that both lncRNAs and miRNAs are closely associated with the development of cardiovascular diseases (CVDs), such as cardiac remodelling, heart failure, myocardial injury and arrhythmia, and that they act as biomarkers, potential therapeutic targets or strong indicators of prognosis; however, the underlying molecular mechanism has not been elucidated. Recently, emerging evidence showed that the novel regulatory mechanism underlying the crosstalk among lncRNAs, miRNAs and mRNAs plays a pivotal role in the pathophysiological processes of CVDs in response to stress stimuli. In this review, I comprehensively summarized the regulatory relationship of lncRNAs, miRNAs and mRNAs and highlighted the important role of the lncRNA‐miRNA‐mRNA axis in CVDs.
  • Publisher: England: John Wiley and Sons Inc
  • Language: English
  • Identifier: ISSN: 1582-1838
    EISSN: 1582-4934
    DOI: 10.1111/jcmm.13866
    PMID: 30188595
  • Source: Journals@Ovid Open Access Journal Collection Rolling
    MEDLINE
    PubMed Central
    Wiley Blackwell Open Access Titles
    ProQuest Central
    DOAJ Directory of Open Access Journals
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