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Diabetic Microvascular Disease: An Endocrine Society Scientific Statement

The journal of clinical endocrinology and metabolism, 2017-12, Vol.102 (12), p.4343-4410 [Peer Reviewed Journal]

Copyright © 2017 Endocrine Society 2017 ;Copyright © Oxford University Press 2015 ;Copyright © 2017 Endocrine Society. ;Copyright © 2017 Endocrine Society ;ISSN: 0021-972X ;EISSN: 1945-7197 ;DOI: 10.1210/jc.2017-01922 ;PMID: 29126250

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Title:
Diabetic Microvascular Disease: An Endocrine Society Scientific Statement
Author: Barrett, Eugene J ; Liu, Zhenqi ; Khamaisi, Mogher ; King, George L ; Klein, Ronald ; Klein, Barbara E K ; Hughes, Timothy M ; Craft, Suzanne ; Freedman, Barry I ; Bowden, Donald W ; Vinik, Aaron I ; Casellini, Carolina M
Subjects: Adipose tissue ; Cerebrovascular Disorders - epidemiology ; Cerebrovascular Disorders - metabolism ; Cerebrovascular Disorders - pathology ; Complications ; Diabetes ; Diabetes mellitus ; Diabetes mellitus (insulin dependent) ; Diabetes mellitus (non-insulin dependent) ; Diabetes Mellitus, Type 1 - complications ; Diabetes Mellitus, Type 2 - complications ; Diabetic Angiopathies - epidemiology ; Diabetic Angiopathies - metabolism ; Diabetic Angiopathies - pathology ; Diabetic Nephropathies - epidemiology ; Diabetic Nephropathies - metabolism ; Diabetic Nephropathies - pathology ; Diabetic Retinopathy - epidemiology ; Diabetic Retinopathy - metabolism ; Diabetic Retinopathy - pathology ; Eye injuries ; Heart diseases ; Humans ; Injury prevention ; Insulin ; Microvasculature ; Muscles ; Nervous system ; Organs ; Peripheral nervous system ; Quality of Life ; Scientific Statement ; Skeletal muscle ; Skin
Is Part Of: The journal of clinical endocrinology and metabolism, 2017-12, Vol.102 (12), p.4343-4410
Description: Abstract Both type 1 and type 2 diabetes adversely affect the microvasculature in multiple organs. Our understanding of the genesis of this injury and of potential interventions to prevent, limit, or reverse injury/dysfunction is continuously evolving. This statement reviews biochemical/cellular pathways involved in facilitating and abrogating microvascular injury. The statement summarizes the types of injury/dysfunction that occur in the three classical diabetes microvascular target tissues, the eye, the kidney, and the peripheral nervous system; the statement also reviews information on the effects of diabetes and insulin resistance on the microvasculature of skin, brain, adipose tissue, and cardiac and skeletal muscle. Despite extensive and intensive research, it is disappointing that microvascular complications of diabetes continue to compromise the quantity and quality of life for patients with diabetes. Hopefully, by understanding and building on current research findings, we will discover new approaches for prevention and treatment that will be effective for future generations. This scientific statement reviews and discusses the microvascular complications of diabetes on an organ-by-organ basis.
Publisher: Washington, DC: Endocrine Society
Language: English
Identifier: ISSN: 0021-972X
EISSN: 1945-7197
DOI: 10.1210/jc.2017-01922
PMID: 29126250
Source: Geneva Foundation Free Medical Journals at publisher websites
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Diabetic Microvascular Disease: An Endocrine Society Scientific Statement

Copyright © 2017 Endocrine Society 2017 ;Copyright © Oxford University Press 2015 ;Copyright © 2017 Endocrine Society. ;Copyright © 2017 Endocrine Society ;ISSN: 0021-972X ;EISSN: 1945-7197 ;DOI: 10.1210/jc.2017-01922 ;PMID: 29126250

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