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Mitochondrial Dysfunction Indirectly Elevates ROS Production by the Endoplasmic Reticulum

Cell metabolism, 2013-08, Vol.18 (2), p.145-146 [Peer Reviewed Journal]

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Title:
Mitochondrial Dysfunction Indirectly Elevates ROS Production by the Endoplasmic Reticulum
Author: Murphy, Michael P.
Subjects: Cytochrome-c Oxidase Deficiency - genetics ; Electron Transport Complex IV - metabolism ; ras Proteins - metabolism ; Reactive Oxygen Species - metabolism ; Saccharomyces cerevisiae - metabolism
Is Part Of: Cell metabolism, 2013-08, Vol.18 (2), p.145-146
Description: Mitochondrial dysfunction is often associated with increased reactive oxygen species (ROS) production by the organelle itself. Leadsham et al. (2013) now show that the link between mitochondrial damage and ROS is more complicated, at least in yeast, where signals from damaged mitochondria increase ROS production from the endoplasmic reticulum surface.
Publisher: United States: Elsevier Inc
Language: English
Identifier: ISSN: 1550-4131
EISSN: 1932-7420
DOI: 10.1016/j.cmet.2013.07.006
PMID: 23931748
Source: Cell Press Free Archives
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