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Biomedical Implications of Heavy Metals Induced Imbalances in Redox Systems

BioMed research international, 2014-01, Vol.2014, p.640754-26 [Peer Reviewed Journal]

Copyright © 2014 Bechan Sharma et al. ;COPYRIGHT 2014 Hindawi Limited ;Copyright © 2014 Bechan Sharma et al. Bechan Sharma et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. ;Copyright © 2014 Bechan Sharma et al. 2014 ;ISSN: 2314-6133 ;EISSN: 2314-6141 ;DOI: 10.1155/2014/640754 ;PMID: 25184144

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Title:
Biomedical Implications of Heavy Metals Induced Imbalances in Redox Systems
Author: Sharma, Bechan ; Singh, Shweta ; Siddiqi, Nikhat J.
Jaeschke, Hartmut
Subjects: Animals ; Antioxidants - metabolism ; Arsenic ; Chelating agents ; Drug dosages ; Enzymes ; Food contamination & poisoning ; Free radicals ; Gallium arsenide ; Health aspects ; Heavy Metal Poisoning ; Heavy metals ; Humans ; Medical research ; Medicine, Experimental ; Metals ; Metals, Heavy - toxicity ; Oxidation-Reduction - drug effects ; Oxidative stress ; Oxidative Stress - drug effects ; Poisoning ; Proteins ; Reactive Nitrogen Species - metabolism ; Reactive Oxygen Species - metabolism ; Review ; Toxicity
Is Part Of: BioMed research international, 2014-01, Vol.2014, p.640754-26
Description: Several workers have extensively worked out the metal induced toxicity and have reported the toxic and carcinogenic effects of metals in human and animals. It is well known that these metals play a crucial role in facilitating normal biological functions of cells as well. One of the major mechanisms associated with heavy metal toxicity has been attributed to generation of reactive oxygen and nitrogen species, which develops imbalance between the prooxidant elements and the antioxidants (reducing elements) in the body. In this process, a shift to the former is termed as oxidative stress. The oxidative stress mediated toxicity of heavy metals involves damage primarily to liver (hepatotoxicity), central nervous system (neurotoxicity), DNA (genotoxicity), and kidney (nephrotoxicity) in animals and humans. Heavy metals are reported to impact signaling cascade and associated factors leading to apoptosis. The present review illustrates an account of the current knowledge about the effects of heavy metals (mainly arsenic, lead, mercury, and cadmium) induced oxidative stress as well as the possible remedies of metal(s) toxicity through natural/synthetic antioxidants, which may render their effects by reducing the concentration of toxic metal(s). This paper primarily concerns the clinicopathological and biomedical implications of heavy metals induced oxidative stress and their toxicity management in mammals.
Publisher: United States: Hindawi Publishing Corporation
Language: English
Identifier: ISSN: 2314-6133
EISSN: 2314-6141
DOI: 10.1155/2014/640754
PMID: 25184144
Source: MEDLINE
PubMed Central
ProQuest Central

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Biomedical Implications of Heavy Metals Induced Imbalances in Redox Systems

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