skip to main content
Language:
Search Limited to: Search Limited to: Resource type Show Results with: Show Results with: Search type Index

Large-vessel involvement in giant cell arteritis: a population-based cohort study of the incidence-trends and prognosis

Annals of the rheumatic diseases, 2013-12, Vol.72 (12), p.1989-1994 [Peer Reviewed Journal]

Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions ;Copyright: 2013 Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions ;ISSN: 0003-4967 ;EISSN: 1468-2060 ;DOI: 10.1136/annrheumdis-2012-202408 ;PMID: 23253927 ;CODEN: ARDIAO

Full text available

  • Title:
    Large-vessel involvement in giant cell arteritis: a population-based cohort study of the incidence-trends and prognosis
  • Author: Kermani, Tanaz A ; Warrington, Kenneth J ; Crowson, Cynthia S ; Ytterberg, Steven R ; Hunder, Gene G ; Gabriel, Sherine E ; Matteson, Eric L
  • Subjects: Aged ; Aged, 80 and over ; Aneurysm, Dissecting - epidemiology ; Aneurysms ; Aortic Aneurysm - epidemiology ; Arterial Occlusive Diseases - epidemiology ; Cardiovascular Disease ; Cohort Studies ; Epidemiology ; Female ; Giant Cell Arteritis ; Giant Cell Arteritis - epidemiology ; Health risk assessment ; Humans ; Incidence ; Male ; Medical records ; Minnesota - epidemiology ; Mortality ; Prognosis ; Survival Analysis
  • Is Part Of: Annals of the rheumatic diseases, 2013-12, Vol.72 (12), p.1989-1994
  • Description: Objectives To evaluate incidence-trends and timing of large-vessel (LV) manifestations in patients with giant cell arteritis (GCA), and to examine the influence of LV manifestations on survival. Methods A population-based incident cohort of patients diagnosed with GCA between 1950 and 2004 was used. LV involvement was defined as large-artery stenosis or aortic aneurysm/dissection that developed in the 1 year before GCA diagnosis or at any time thereafter. Patients were followed up until death or 31 December 2009. Results The study included 204 patients, 80% women, mean age at diagnosis of GCA 76.0 years (±8.2 years). Median length of follow-up was 8.8 years. The cumulative incidence of any LV manifestation at 10 years was 24.9% for patients diagnosed with GCA between 1980 and 2004 compared with 8.3% for patients diagnosed with GCA between 1950 and 1979. The incidence of any LV event was high within the first year of GCA diagnosis. The incidence of aortic aneurysm/dissection increased 5 years after GCA diagnosis. Compared with the general population, survival was decreased in patients with an aortic aneurysm/dissection (standardized mortality ratio (SMR) 2.63; 95% CI 1.78 to 3.73) but not in patients with large-artery stenosis (SMR 1.44; 95% CI 0.87 to 2.25). Patients with GCA and aortic manifestations had a higher than expected number of deaths from cardiovascular and pulmonary causes than the general population. Among patients with GCA, aortic manifestations were associated with increased mortality (HR=3.4; 95% CI 2.2 to 5.4). Conclusions Vigilance and screening for aortic aneurysms should be considered in all patients 5 years after the incidence of GCA. Aortic aneurysm/dissection is associated with increased mortality in GCA.
  • Publisher: England: BMJ Publishing Group Ltd and European League Against Rheumatism
  • Language: English
  • Identifier: ISSN: 0003-4967
    EISSN: 1468-2060
    DOI: 10.1136/annrheumdis-2012-202408
    PMID: 23253927
    CODEN: ARDIAO
  • Source: MEDLINE
    Alma/SFX Local Collection
    ProQuest Central
Back to results list
INSPIRE LIBRARY - TON DUC THANG UNIVERSITY (84-028) 37 755 057 Feedback
19 Nguyen Huu Tho St. Dist.7, HCM thuvien@tdtu.edu.vn

Copyright © 2017 INSPIRE LIBRARY - TON DUC THANG UNIVERSITY

Searching Remote Databases, Please Wait