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Peripartum cardiomyopathy

BMJ (Online), 2019-01, Vol.364, p.k5287-k5287 [Peer Reviewed Journal]

Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions. ;Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go tohttp://group.bmj.com/group/rights-licensing/permissions2019BMJ ;ISSN: 0959-8138 ;EISSN: 1756-1833 ;DOI: 10.1136/bmj.k5287 ;PMID: 30700415

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Title:
Peripartum cardiomyopathy
Author: Honigberg, Michael C ; Givertz, Michael M
Subjects: Age ; Animals ; Arrhythmia ; Births ; Bromocriptine ; Cardiology ; Cardiomyopathies - diagnosis ; Cardiomyopathies - drug therapy ; Cardiomyopathies - epidemiology ; Cardiomyopathies - etiology ; Cardiomyopathy ; Congestive heart failure ; Directive Counseling ; Female ; Fetuses ; Gestation ; Health risk assessment ; Heart failure ; Heart transplantation ; Humans ; Hypertension ; Peripartum Period ; Point mutation ; Postpartum ; Postpartum period ; Pre-eclampsia ; Preeclampsia ; Pregnancy ; Pregnancy complications ; Pregnancy Complications, Cardiovascular - diagnosis ; Pregnancy Complications, Cardiovascular - drug therapy ; Pregnancy Complications, Cardiovascular - epidemiology ; Pregnancy Complications, Cardiovascular - etiology ; Prognosis ; Risk Factors ; Syngeneic grafts ; Thromboembolism ; Womens health
Is Part Of: BMJ (Online), 2019-01, Vol.364, p.k5287-k5287
Description: Peripartum cardiomyopathy (PPCM) is a rare, often dilated, cardiomyopathy with systolic dysfunction that presents in late pregnancy or, more commonly, the early postpartum period. Although the condition is prevalent worldwide, women with black ancestry seem to be at greatest risk, and the condition has a particularly high incidence in Nigeria and Haiti. Other risk factors include pre-eclampsia, advanced maternal age, and multiple gestation pregnancy. Although the complete pathophysiology of peripartum cardiomyopathy remains unclear, research over the past decade suggests the importance of vasculo-hormonal pathways in women with underlying susceptibility. At least some women with the condition harbor an underlying sarcomere gene mutation. More than half of affected women recover systolic function, although some are left with a chronic cardiomyopathy, and a minority requires mechanical support or cardiac transplantation (or both). Other potential complications include thromboembolism and arrhythmia. Currently, management entails standard treatments for heart failure with reduced ejection fraction, with attention to minimizing potential adverse effects on the fetus in women who are still pregnant. Bromocriptine is one potential disease specific treatment under investigation. In this review, we summarize the current literature on peripartum cardiomyopathy, as well as gaps in the understanding of this condition and future research directions.
Publisher: England: BMJ Publishing Group LTD
Language: English
Identifier: ISSN: 0959-8138
EISSN: 1756-1833
DOI: 10.1136/bmj.k5287
PMID: 30700415
Source: AUTh Library subscriptions: ProQuest Central
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Peripartum cardiomyopathy

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