Language:

Relative Timing Between Kappa Opioid Receptor Activation and Cocaine Determines the Impact on Reward and Dopamine Release

Neuropsychopharmacology (New York, N.Y.), 2016-03, Vol.41 (4), p.989-1002 [Peer Reviewed Journal]

Copyright Nature Publishing Group Mar 2016 ;Copyright © 2016 American College of Neuropsychopharmacology 2016 American College of Neuropsychopharmacology ;ISSN: 0893-133X ;EISSN: 1740-634X ;DOI: 10.1038/npp.2015.226 ;PMID: 26239494 ;CODEN: NEROEW

Full text available

Citations Cited by

Actions
1. Add to My Research
2. Remove from My Research
3. E-mail
4. Print
5. Permalink
6. Citation
7. EasyBib
8. EndNote
9. RefWorks
10. Delicious
11. Export RIS
12. Export BibTeX

Title:
Relative Timing Between Kappa Opioid Receptor Activation and Cocaine Determines the Impact on Reward and Dopamine Release
Author: Chartoff, Elena H ; Ebner, Shayla R ; Sparrow, Angela ; Potter, David ; Baker, Phillip M ; Ragozzino, Michael E ; Roitman, Mitchell F
Subjects: Affect - drug effects ; Affect - physiology ; Animals ; Cocaine - administration & dosage ; Diterpenes, Clerodane - administration & dosage ; Dopamine - genetics ; Dopamine - metabolism ; Male ; Nucleus Accumbens - drug effects ; Nucleus Accumbens - metabolism ; Original ; Rats ; Rats, Sprague-Dawley ; Receptors, Opioid, kappa - agonists ; Receptors, Opioid, kappa - metabolism ; Receptors, Opioid, kappa - physiology ; Reward ; Self Stimulation - drug effects ; Time Factors ; Ventral Tegmental Area - drug effects ; Ventral Tegmental Area - metabolism
Is Part Of: Neuropsychopharmacology (New York, N.Y.), 2016-03, Vol.41 (4), p.989-1002
Description: Negative affective states can increase the rewarding value of drugs of abuse and promote drug taking. Chronic cocaine exposure increases levels of the neuropeptide dynorphin, an endogenous ligand at kappa opioid receptors (KOR) that suppresses dopamine release in the nucleus accumbens (NAc) and elicits negative affective states upon drug withdrawal. However, there is evidence that the effects of KOR activation on affective state are biphasic: immediate aversive effects are followed by delayed increases in reward. The impact of KOR-induced affective states on reward-related effects of cocaine over time is not known. We hypothesize that the initial aversive effects of KOR activation increase, whereas the delayed rewarding effects decrease, the net effects of cocaine on reward and dopamine release. We treated rats with cocaine at various times (15 min to 48 h) after administration of the selective KOR agonist salvinorin A (salvA). Using intracranial self-stimulation and fast scan cyclic voltammetry, we found that cocaine-induced increases in brain stimulation reward and evoked dopamine release in the NAc core were potentiated when cocaine was administered within 1 h of salvA, but attenuated when administered 24 h after salvA. Quantitative real-time PCR was used to show that KOR and prodynorphin mRNA levels were decreased in the NAc, whereas tyrosine hydroxylase and dopamine transporter mRNA levels and tissue dopamine content were increased in the ventral tegmental area 24 h post-salvA. These findings raise the possibility that KOR activation-as occurs upon withdrawal from chronic cocaine-modulates vulnerability to cocaine in a time-dependent manner.
Publisher: England: Nature Publishing Group
Language: English
Identifier: ISSN: 0893-133X
EISSN: 1740-634X
DOI: 10.1038/npp.2015.226
PMID: 26239494
CODEN: NEROEW
Source: ProQuest One Psychology
GFMER Free Medical Journals
MEDLINE
PubMed Central
ProQuest Central

Back to results list


INSPIRE LIBRARY - TON DUC THANG UNIVERSITY	(84-028) 37 755 057	Feedback
19 Nguyen Huu Tho St. Dist.7, HCM	thuvien@tdtu.edu.vn	Feedback

Relative Timing Between Kappa Opioid Receptor Activation and Cocaine Determines the Impact on Reward and Dopamine Release

Copyright Nature Publishing Group Mar 2016 ;Copyright © 2016 American College of Neuropsychopharmacology 2016 American College of Neuropsychopharmacology ;ISSN: 0893-133X ;EISSN: 1740-634X ;DOI: 10.1038/npp.2015.226 ;PMID: 26239494 ;CODEN: NEROEW

Searching Remote Databases, Please Wait