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Screening for fetal aneuploidies at 11 to 13 weeks

Prenatal diagnosis, 2011-01, Vol.31 (1), p.7-15 [Peer Reviewed Journal]

Copyright © 2011 John Wiley & Sons, Ltd. ;ISSN: 0197-3851 ;ISSN: 1097-0223 ;EISSN: 1097-0223 ;DOI: 10.1002/pd.2637 ;PMID: 21210475

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Title:
Screening for fetal aneuploidies at 11 to 13 weeks
Author: Nicolaides, Kypros H.
Subjects: aneuploidies ; Aneuploidy ; Bone ; Chorionic Gonadotropin, beta Subunit, Human - blood ; Down Syndrome - diagnosis ; False Positive Reactions ; Female ; Fetuses ; first-trimester screening ; Gestational Age ; hepatic artery ; Humans ; nuchal translucency ; Nuchal Translucency Measurement ; Pituitary (anterior) ; Pregnancy ; Pregnancy-Associated Plasma Protein-A - analysis ; Prenatal diagnosis ; Prenatal Diagnosis - methods ; serum free β-hCG ; serum PAPP-A ; tricuspid valve ; Trisomy ; trisomy 21 ; Twins ; Ultrasonography, Prenatal ; Ultrasound
Is Part Of: Prenatal diagnosis, 2011-01, Vol.31 (1), p.7-15
Description: Effective screening for major aneuploidies can be provided in the first trimester of pregnancy. Screening by a combination of fetal nuchal translucency and maternal serum free‐β‐human chorionic gonadotrophin and pregnancy‐associated plasma protein‐A can identify about 90% of fetuses with trisomy 21 and other major aneuploidies for a false‐positive rate of 5%. Improvement in the performance of first‐trimester screening can be achieved by firstly, inclusion in the ultrasound examination assessment of the nasal bone and flow in the ductus venosus, hepatic artery and across the tricuspid valve, and secondly, carrying out the biochemical test at 9 to 10 weeks and the ultrasound scan at 12 weeks. Copyright © 2011 John Wiley & Sons, Ltd.
Publisher: Chichester, UK: John Wiley & Sons, Ltd
Language: English
Identifier: ISSN: 0197-3851
ISSN: 1097-0223
EISSN: 1097-0223
DOI: 10.1002/pd.2637
PMID: 21210475
Source: MEDLINE
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Screening for fetal aneuploidies at 11 to 13 weeks

Copyright © 2011 John Wiley & Sons, Ltd. ;ISSN: 0197-3851 ;ISSN: 1097-0223 ;EISSN: 1097-0223 ;DOI: 10.1002/pd.2637 ;PMID: 21210475

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