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Cardiovascular Safety of Celecoxib, Naproxen, or Ibuprofen for Arthritis

The New England journal of medicine, 2016-12, Vol.375 (26), p.2519-2529 [Peer Reviewed Journal]

Copyright © 2016 Massachusetts Medical Society. All rights reserved. ;Copyright Massachusetts Medical Society Dec 29, 2016 ;ISSN: 0028-4793 ;EISSN: 1533-4406 ;DOI: 10.1056/NEJMoa1611593 ;PMID: 27959716 ;CODEN: NEJMAG

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Title:
Cardiovascular Safety of Celecoxib, Naproxen, or Ibuprofen for Arthritis
Author: Nissen, Steven E ; Yeomans, Neville D ; Solomon, Daniel H ; Lüscher, Thomas F ; Libby, Peter ; Husni, M. Elaine ; Graham, David Y ; Borer, Jeffrey S ; Wisniewski, Lisa M ; Wolski, Katherine E ; Wang, Qiuqing ; Menon, Venu ; Ruschitzka, Frank ; Gaffney, Michael ; Beckerman, Bruce ; Berger, Manuela F ; Bao, Weihang ; Lincoff, A. Michael
Subjects: Aged ; Analgesics ; Anemia ; Anti-Inflammatory Agents, Non-Steroidal - adverse effects ; Anti-Inflammatory Agents, Non-Steroidal - therapeutic use ; Arthritis ; Arthritis - drug therapy ; Cardiovascular disease ; Cardiovascular diseases ; Cardiovascular Diseases - chemically induced ; Cardiovascular Diseases - mortality ; Care and treatment ; Celecoxib ; Celecoxib - adverse effects ; Celecoxib - therapeutic use ; Cerebral infarction ; Collaboration ; Committees ; Cyclooxygenase 2 Inhibitors - adverse effects ; Cyclooxygenase 2 Inhibitors - therapeutic use ; Diagnosis ; Dosage and administration ; Drug dosages ; FDA approval ; Fees & charges ; Female ; Gastrointestinal Diseases - chemically induced ; Hemorrhage ; Humans ; Ibuprofen ; Ibuprofen - adverse effects ; Ibuprofen - therapeutic use ; Intention to Treat Analysis ; Kidney Diseases - chemically induced ; Male ; Middle Aged ; Motivation ; Myocardial infarction ; Naproxen ; Naproxen - adverse effects ; Naproxen - therapeutic use ; Nonsteroidal anti-inflammatory drugs ; Osteoarthritis ; Pain ; Pain management ; Patients ; Pharmaceuticals ; Rheumatoid arthritis ; Risk ; Risk factors ; Safety ; Safety and security measures ; Side effects ; Statistical analysis
Is Part Of: The New England journal of medicine, 2016-12, Vol.375 (26), p.2519-2529
Description: This randomized trial involving patients with osteoarthritis or rheumatoid arthritis who were at increased cardiovascular risk showed the noninferiority of celecoxib to naproxen or ibuprofen with respect to cardiovascular safety. Nonsteroidal antiinflammatory drugs (NSAIDs) were introduced in the 1960s and became the most widely prescribed class of drugs in the world, with more than 100 million prescriptions issued annually in the United States alone. 1 NSAIDs inhibit cyclooxygenase (COX), which reduces pain and inflammation through the inhibition of prostaglandins. However, the COX enzyme is also present in gastric mucosa, where it stimulates gastroprotective prostaglandins. The identification of two isoforms, COX-1 and COX-2, and the recognition that antiinflammatory and analgesic effects are mediated through COX-2 inhibition — whereas the gastrointestinal toxic effects are linked to COX-1 inhibition — resulted in the development . . .
Publisher: United States: Massachusetts Medical Society
Language: English
Identifier: ISSN: 0028-4793
EISSN: 1533-4406
DOI: 10.1056/NEJMoa1611593
PMID: 27959716
CODEN: NEJMAG
Source: ProQuest One Psychology
MEDLINE
ProQuest Central

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Cardiovascular Safety of Celecoxib, Naproxen, or Ibuprofen for Arthritis

Copyright © 2016 Massachusetts Medical Society. All rights reserved. ;Copyright Massachusetts Medical Society Dec 29, 2016 ;ISSN: 0028-4793 ;EISSN: 1533-4406 ;DOI: 10.1056/NEJMoa1611593 ;PMID: 27959716 ;CODEN: NEJMAG

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