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Cardiovascular Disease, Cancer, and Mortality Among People With Type 2 Diabetes and Alcoholic or Nonalcoholic Fatty Liver Disease Hospital Admission

Diabetes care, 2018-02, Vol.41 (2), p.341-347 [Peer Reviewed Journal]

2017 by the American Diabetes Association. ;Copyright American Diabetes Association Feb 1, 2018 ;ISSN: 0149-5992 ;EISSN: 1935-5548 ;DOI: 10.2337/dc17-1590 ;PMID: 29167212

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Title:
Cardiovascular Disease, Cancer, and Mortality Among People With Type 2 Diabetes and Alcoholic or Nonalcoholic Fatty Liver Disease Hospital Admission
Author: Wild, Sarah H ; Walker, Jeremy J ; Morling, Joanne R ; McAllister, David A ; Colhoun, Helen M ; Farran, Bassam ; McGurnaghan, Stuart ; McCrimmon, Rory ; Read, Stephanie H ; Sattar, Naveed ; Byrne, Christopher D
Subjects: Adult ; Aged ; Aged, 80 and over ; Atomic layer epitaxy ; Cancer ; Carcinoma, Hepatocellular - complications ; Carcinoma, Hepatocellular - epidemiology ; Carcinoma, Hepatocellular - mortality ; Carcinoma, Hepatocellular - therapy ; Cardiovascular disease ; Cardiovascular diseases ; Cardiovascular Diseases - epidemiology ; Cardiovascular Diseases - etiology ; Cardiovascular Diseases - mortality ; Cardiovascular Diseases - therapy ; Chemical vapor deposition ; Diabetes ; Diabetes Complications - epidemiology ; Diabetes Complications - mortality ; Diabetes Complications - therapy ; Diabetes mellitus ; Diabetes mellitus (non-insulin dependent) ; Diabetes Mellitus, Type 2 - complications ; Diabetes Mellitus, Type 2 - epidemiology ; Diabetes Mellitus, Type 2 - mortality ; Diabetes Mellitus, Type 2 - therapy ; Fatty liver ; Female ; Hazards ; Health risks ; Hepatocellular carcinoma ; Hospitalization - statistics & numerical data ; Humans ; Liver ; Liver diseases ; Liver Diseases, Alcoholic - complications ; Liver Diseases, Alcoholic - epidemiology ; Liver Diseases, Alcoholic - mortality ; Liver Diseases, Alcoholic - therapy ; Liver Neoplasms - complications ; Liver Neoplasms - epidemiology ; Liver Neoplasms - mortality ; Liver Neoplasms - therapy ; Male ; Middle Aged ; Mortality ; Neoplasms - epidemiology ; Neoplasms - mortality ; Neoplasms - therapy ; Non-alcoholic Fatty Liver Disease - complications ; Non-alcoholic Fatty Liver Disease - epidemiology ; Non-alcoholic Fatty Liver Disease - mortality ; Non-alcoholic Fatty Liver Disease - therapy ; Patient Admission - statistics & numerical data ; Patient admissions ; Population studies ; Regression analysis ; Regression models ; Research design ; Retrospective Studies ; Risk analysis ; Risk Factors ; Scotland - epidemiology
Is Part Of: Diabetes care, 2018-02, Vol.41 (2), p.341-347
Description: To describe associations between alcoholic liver disease (ALD) or nonalcoholic fatty liver disease (NAFLD) hospital admission and cardiovascular disease (CVD), cancer, and mortality in people with type 2 diabetes mellitus (T2DM). We performed a retrospective cohort study by using linked population-based routine data from diabetes registry, hospital, cancer, and death records for people aged 40-89 years diagnosed with T2DM in Scotland between 2004 and 2013 who had one or more hospital admission records. Liver disease and outcomes were identified by using ICD-9 and ICD-10 codes. We estimated hazard ratios (HRs) from Cox proportional hazards regression models, adjusting for key risk factors. A total of 134,368 people with T2DM (1,707 with ALD and 1,452 with NAFLD) were studied, with a mean follow-up of 4.3 years for CVD and 4.7 years for mortality. Among those with ALD, NAFLD, or without liver disease hospital records 378, 320, and 21,873 CVD events; 268, 176, and 15,101 cancers; and 724, 221, and 16,203 deaths were reported, respectively. For ALD and NAFLD, respectively, adjusted HRs (95% CIs) compared with the group with no record of liver disease were 1.59 (1.43, 1.76) and 1.70 (1.52, 1.90) for CVD, 40.3 (28.8, 56.5) and 19.12 (11.71, 31.2) for hepatocellular carcinoma (HCC), 1.28 (1.12, 1.47) and 1.10 (0.94, 1.29) for non-HCC cancer, and 4.86 (4.50, 5.24) and 1.60 (1.40, 1.83) for all-cause mortality. Hospital records of ALD or NAFLD are associated to varying degrees with an increased risk of CVD, cancer, and mortality among people with T2DM.
Publisher: United States: American Diabetes Association
Language: English
Identifier: ISSN: 0149-5992
EISSN: 1935-5548
DOI: 10.2337/dc17-1590
PMID: 29167212
Source: Geneva Foundation Free Medical Journals at publisher websites
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Cardiovascular Disease, Cancer, and Mortality Among People With Type 2 Diabetes and Alcoholic or Nonalcoholic Fatty Liver Disease Hospital Admission

2017 by the American Diabetes Association. ;Copyright American Diabetes Association Feb 1, 2018 ;ISSN: 0149-5992 ;EISSN: 1935-5548 ;DOI: 10.2337/dc17-1590 ;PMID: 29167212

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