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Sex-specific genetic architecture in response to American and ketogenic diets

International Journal of Obesity, 2021-06, Vol.45 (6), p.1284-1297 [Peer Reviewed Journal]

COPYRIGHT 2021 Nature Publishing Group ;The Author(s), under exclusive licence to Springer Nature Limited part of Springer Nature 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;The Author(s), under exclusive licence to Springer Nature Limited part of Springer Nature 2021 ;ISSN: 0307-0565 ;EISSN: 1476-5497 ;DOI: 10.1038/s41366-021-00785-7 ;PMID: 33723359

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Title:
Sex-specific genetic architecture in response to American and ketogenic diets
Author: Salvador, Anna C ; Arends, Danny ; Barrington, William T ; Elsaadi, Ahmed M ; Brockmann, Gudrun A ; Threadgill, David W
Subjects: Adipose Tissue - metabolism ; Adipose Tissue - physiology ; Animals ; Body composition ; Body fat ; Carbohydrate composition ; Carbohydrates ; Cholesterol ; Diet ; Diet, Ketogenic ; Diet, Western ; Gene mapping ; Genetic aspects ; Genetic diversity ; Genetic variance ; High density lipoprotein ; Identification and classification ; Ketogenic diet ; Mice ; Nutrition ; Physiological aspects ; Physiological responses ; Quantitative trait loci ; Quantitative Trait Loci - genetics ; Sex ; Sex Factors
Is Part Of: International Journal of Obesity, 2021-06, Vol.45 (6), p.1284-1297
Description: There is a growing appreciation for individual responses to diet. In a previous study, mouse strain-specific responses to American and ketogenic diets were observed. In this study, we searched for genetic variants underlying differences in the responses to American and ketogenic diets between C57BL/6J (B6) and FVB/NJ (FVB) mouse strains. Genetic mapping of fat and lean mass gain revealed QTLs on Chromosome (Chr) 1 at 191.6 Mb (Fmgq1) (P < 0.001, CI = 180.2-194.4 Mb), Chr5 at 73.7 Mb (Fmgq2, Lmgq1) (P < 0.001, CI = 66.1-76.6 Mb), and Chr7 at 40.5 Mb (Fmgq3) (P < 0.01, CI = 36.6-44.5 Mb). Analysis of serum HDL cholesterol concentration identified a significant (P < 0.001, CI = 160.6-176.1 Mb) QTL on Chr1 at 168.6 Mb (Hdlq1). Causal network inference suggests that HDL cholesterol and fat mass gain are both linked to Fmgq1. Strong sex effects were identified at both Fmgq2 and Lmgq1, which are also diet-dependent. Interestingly, Fmgq2 and Fmgq3 affect fat gain directly, while Fmgq1 influences fat gain directly and via an intermediate change in serum cholesterol. These results demonstrate how precision nutrition will be advanced through the integration of genetic variation and sex in physiological responses to diets varied in carbohydrate composition.
Publisher: England: Nature Publishing Group
Language: English
Identifier: ISSN: 0307-0565
EISSN: 1476-5497
DOI: 10.1038/s41366-021-00785-7
PMID: 33723359
Source: ProQuest One Psychology
MEDLINE
ProQuest Central

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Sex-specific genetic architecture in response to American and ketogenic diets

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