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Anterior Lamina Cribrosa Surface Depth in Open-Angle Glaucoma: Relationship with the Position of the Central Retinal Vessel Trunk

PloS one, 2016-06, Vol.11 (6), p.e0158443-e0158443 [Peer Reviewed Journal]

COPYRIGHT 2016 Public Library of Science ;COPYRIGHT 2016 Public Library of Science ;2016 Oh et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;2016 Oh et al 2016 Oh et al ;ISSN: 1932-6203 ;EISSN: 1932-6203 ;DOI: 10.1371/journal.pone.0158443 ;PMID: 27355646

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Title:
Anterior Lamina Cribrosa Surface Depth in Open-Angle Glaucoma: Relationship with the Position of the Central Retinal Vessel Trunk
Author: Oh, Baek-Lok ; Lee, Eun Ji ; Kim, Hyunjoong ; Girard, Michaël J A ; Mari, Jean Martial ; Kim, Tae-Woo
Baird, Paul N
Subjects: Adolescent ; Adult ; Age ; Aged ; Aged, 80 and over ; Algorithms ; Biology and Life Sciences ; Care and treatment ; Cornea ; Deformation ; Deformation resistance ; Diagnosis ; Extracellular matrix ; Eye (anatomy) ; Female ; Glaucoma ; Glaucoma, Open-Angle - pathology ; Horizontal cells ; Hospitals ; Humans ; Intraocular Pressure ; Male ; Medical imaging ; Medicine and Health Sciences ; Middle Aged ; Multivariate analysis ; Observer Variation ; Open-angle glaucoma ; Optic nerve ; Optic Nerve - pathology ; Optic Nerve Diseases ; Optical Coherence Tomography ; Optics ; Patients ; Physical Sciences ; Prospective Studies ; Refractive Errors ; Retina ; Retinal Vessels - pathology ; Thickness ; Visual fields ; Young Adult
Is Part Of: PloS one, 2016-06, Vol.11 (6), p.e0158443-e0158443
Description: To determine the factors influencing the anterior lamina cribrosa (LC) surface depth (LCD) in patients with open-angle glaucoma (OAG), focusing on the association between LCD and the position of the central retinal vessel trunk (CRVT) at the anterior LC surface. Optic nerve heads of 205 OAG eyes were scanned using swept-source optical coherence tomography (SS-OCT). After processing the images using adaptive compensation, the LCD was determined from 11 horizontal B-scan images that divided the optic disc vertically into 12 equal parts. Eyes were divided into two groups (central or peripheral) according to where the CRVT exits from the anterior LC surface. The influence of CRVT position on LCD was evaluated, taking into account age, gender, untreated intraocular pressure (IOP), IOP at optic-disc scanning, retinal nerve fiber layer (RNFL) thickness, visual-field mean deviation, central corneal thickness, and axial length. Patients in the peripheral CRVT group were younger and more myopic, and had a larger mean LCD and thinner global RNFL than those in the central CRVT group (all P≤0.023). On multivariate analysis, the peripheral CRVT location was significantly associated with a larger LCD (P = 0.002), together with the significant association of younger age (P<0.001), higher untreated IOP (P = 0.010), and thinner RNFL (P = 0.003) on the larger LCD. In OAG, CRVT location was an independent factor influencing the LCD, together with age, untreated IOP, and global RNFL thickness. The data indicate that the CRVT may contribute to the resistance of the LC against deformation. A longitudinal prospective observation is required to clarify this relationship.
Publisher: United States: Public Library of Science
Language: English
Identifier: ISSN: 1932-6203
EISSN: 1932-6203
DOI: 10.1371/journal.pone.0158443
PMID: 27355646
Source: GFMER Free Medical Journals
MEDLINE
PubMed Central
Public Library of Science (PLoS)
ProQuest Central
DOAJ Directory of Open Access Journals

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Anterior Lamina Cribrosa Surface Depth in Open-Angle Glaucoma: Relationship with the Position of the Central Retinal Vessel Trunk

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