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A programmable polymer library that enables the construction of stimuli-responsive nanocarriers containing logic gates

Nature chemistry, 2020-04, Vol.12 (4), p.381-390 [Peer Reviewed Journal]

2020© The Author(s), under exclusive licence to Springer Nature Limited 2020 ;ISSN: 1755-4330 ;EISSN: 1755-4349 ;DOI: 10.1038/s41557-020-0426-3 ;PMID: 32152477

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Title:
A programmable polymer library that enables the construction of stimuli-responsive nanocarriers containing logic gates
Author: Zhang, Penghui ; Gao, Di ; An, Keli ; Shen, Qi ; Wang, Chen ; Zhang, Yuchao ; Pan, Xiaoshu ; Chen, Xigao ; Lyv, Yifan ; Cui, Cheng ; Liang, Tingxizi ; Duan, Xiaoman ; Liu, Jie ; Yang, Tielin ; Hu, Xiaoxiao ; Zhu, Jun-Jie ; Xu, Feng ; Tan, Weihong
Subjects: Anilides - chemistry ; Anilides - pharmacology ; Animals ; Antineoplastic Agents - chemistry ; Antineoplastic Agents - pharmacology ; Biomarkers ; Biomaterials ; Biomedical materials ; Cell Line, Tumor ; Cell therapy ; Cisplatin - chemistry ; Cisplatin - pharmacology ; Construction ; Drug Carriers - chemical synthesis ; Drug Carriers - chemistry ; Drug Carriers - metabolism ; Drug delivery systems ; Drug Liberation ; Female ; Gates ; Glutathione - metabolism ; Humans ; Hydrogen Peroxide - metabolism ; Kinases ; Libraries ; Logic ; Logic circuits ; Mice, Nude ; Nanoparticles - chemistry ; Nanoparticles - metabolism ; Nanotechnology devices ; Plug and play ; Polyethylene Glycols - chemical synthesis ; Polyethylene Glycols - chemistry ; Polyethylene Glycols - metabolism ; Polyethyleneimine - chemical synthesis ; Polyethyleneimine - chemistry ; Polyethyleneimine - metabolism ; Polymers ; Precision medicine ; Proof of Concept Study ; Pyridines - chemistry ; Pyridines - pharmacology ; Ribonucleic acid ; RNA ; RNA, Small Interfering - chemistry ; RNA, Small Interfering - pharmacology ; siRNA ; Stem cells ; Stimuli ; Structural hierarchy ; Tissue engineering ; Xenograft Model Antitumor Assays
Is Part Of: Nature chemistry, 2020-04, Vol.12 (4), p.381-390
Description: Stimuli-responsive biomaterials that contain logic gates hold great potential for detecting and responding to pathological markers as part of clinical therapies. However, a major barrier is the lack of a generalized system that can be used to easily assemble different ligand-responsive units to form programmable nanodevices for advanced biocomputation. Here we develop a programmable polymer library by including responsive units in building blocks with similar structure and reactivity. Using these polymers, we have developed a series of smart nanocarriers with hierarchical structures containing logic gates linked to self-immolative motifs. Designed with disease biomarkers as inputs, our logic devices showed site-specific release of multiple therapeutics (including kinase inhibitors, drugs and short interfering RNA) in vitro and in vivo. We expect that this 'plug and play' platform will be expanded towards smart biomaterial engineering for therapeutic delivery, precision medicine, tissue engineering and stem cell therapy.
Publisher: England: Nature Publishing Group
Language: English
Identifier: ISSN: 1755-4330
EISSN: 1755-4349
DOI: 10.1038/s41557-020-0426-3
PMID: 32152477
Source: MEDLINE
ProQuest Central

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A programmable polymer library that enables the construction of stimuli-responsive nanocarriers containing logic gates

2020© The Author(s), under exclusive licence to Springer Nature Limited 2020 ;ISSN: 1755-4330 ;EISSN: 1755-4349 ;DOI: 10.1038/s41557-020-0426-3 ;PMID: 32152477

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