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Bisphenol A and Peripheral Arterial Disease: Results from the NHANES

Environmental health perspectives, 2012-09, Vol.120 (9), p.1297-1300 [Peer Reviewed Journal]

2015 INIST-CNRS ;COPYRIGHT 2012 National Institute of Environmental Health Sciences ;COPYRIGHT 2012 National Institute of Environmental Health Sciences ;Copyright National Institute of Environmental Health Sciences Sep 2012 ;2012 ;ISSN: 0091-6765 ;EISSN: 1552-9924 ;DOI: 10.1289/ehp.1104114 ;PMID: 22645278 ;CODEN: EVHPAZ

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Title:
Bisphenol A and Peripheral Arterial Disease: Results from the NHANES
Author: Shankar, Anoop ; Teppala, Srinivas ; Sabanayagam, Charumathi
Subjects: Adult ; Animal experimentation ; Ankle Brachial Index ; Benzhydryl Compounds - urine ; Biological and medical sciences ; Bisphenol-A ; Bisphenols ; Body mass index ; Business publications audits ; Cardiovascular diseases ; Cigarette smoking ; Development and progression ; Diabetes mellitus ; Diabetes. Impaired glucose tolerance ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Environment. Living conditions ; Environmental Exposure ; Environmental Monitoring ; Environmental Pollutants - urine ; Environmentally induced diseases ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Female ; Health aspects ; Health surveys ; Humans ; Hypertension ; Logistic Models ; Male ; Medical sciences ; Middle Aged ; Nutrition Surveys ; Odds Ratio ; Peripheral Arterial Disease - chemically induced ; Peripheral Arterial Disease - epidemiology ; Peripheral artery disease ; Phenols - urine ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Risk Factors ; Toxicology ; Type 2 diabetes mellitus ; United States - epidemiology
Is Part Of: Environmental health perspectives, 2012-09, Vol.120 (9), p.1297-1300
Description: Background: Bisphenol A (BPA) is a common chemical used in the manufacture of polycarbonate plastics and epoxy resins, and > 93% of U. S. adults have detectable levels of urinary BPA. Recent animal studies have suggested that BPA exposure may have a role in several mechanisms involved in the development of cardiovascular disease (CVD), including weight gain, insulin resistance, thyroid dysfunction, endothelial dysfunction, and oxidative stress. However, few human studies have examined the association between markers of BPA exposure and CVD. Peripheral arterial disease (PAD) is a subclinical measure of atherosclerotic vascular disease and a strong independent risk factor for CVD and mortality. Objective: We examined the association between urinary BPA levels and PAD in a nationally representative sample of U.S. adults. Methods: We analyzed data from 745 participants in the National Health and Nutritional Examination Survey 2003-2004. We estimated associations between urinary BPA levels (in tertiles) and PAD (ankle-brachial index < 0.9, n = 63) using logistic regression models adjusted for potential confounders (age, sex, race/ethnicity, education, smoking, body mass index, diabetes mellitus, hypertension, urinary creatinine, estimated glomerular filtration rate, and serum cholesterol levels). Results: We observed a significant, positive association between increasing levels of urinary BPA and PAD before and after adjusting for confounders. The multivariable-adjusted odds ratio for PAD associated with the highest versus lowest tertile of urinary BPA was 2.69 (95% confidence interval: 1.02, 7.09; p-trend = 0.01). Conclusions: Urinary BPA levels were significantly associated with PAD, independent of traditional CVD risk factors.
Publisher: Research Triangle Park, NC: National Institute of Environmental Health Sciences
Language: English
Identifier: ISSN: 0091-6765
EISSN: 1552-9924
DOI: 10.1289/ehp.1104114
PMID: 22645278
CODEN: EVHPAZ
Source: U.S. Government Documents
MEDLINE
PubMed Central
ProQuest Central
DOAJ Directory of Open Access Journals

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Bisphenol A and Peripheral Arterial Disease: Results from the NHANES

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