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Similarity of Bisphenol A Pharmacokinetics in Rhesus Monkeys and Mice: Relevance for Human Exposure

Environmental health perspectives, 2011-04, Vol.119 (4), p.422-430 [Peer Reviewed Journal]

2015 INIST-CNRS ;COPYRIGHT 2011 National Institute of Environmental Health Sciences ;COPYRIGHT 2011 National Institute of Environmental Health Sciences ;Copyright National Institute of Environmental Health Sciences Apr 2011 ;Distributed under a Creative Commons Attribution 4.0 International License ;2011 ;ISSN: 0091-6765 ;EISSN: 1552-9924 ;DOI: 10.1289/ehp.1002514 ;PMID: 20855240 ;CODEN: EVHPAZ

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Title:
Similarity of Bisphenol A Pharmacokinetics in Rhesus Monkeys and Mice: Relevance for Human Exposure
Author: Taylor, Julia A. ; vom Saal, Frederick S. ; Welshons, Wade V. ; Drury, Bertram ; Rottinghaus, George ; Hunt, Patricia A. ; Toutain, Pierre-Louis ; Laffont, Céline M. ; VandeVoort, Catherine A.
Subjects: Administered dose ; Adults ; Animals ; Benzhydryl Compounds ; Biological and medical sciences ; Biological monitoring ; Bisphenol A ; Bisphenols ; Business publications audits ; Cadmium ; Chemical and industrial products toxicology. Toxic occupational diseases ; Dosage ; Endocrine Disruptors - blood ; Endocrine Disruptors - metabolism ; Environment. Living conditions ; Environmental Exposure - analysis ; Environmental Exposure - statistics & numerical data ; Environmental Pollutants - blood ; Environmental Pollutants - metabolism ; Female animals ; Females ; Health aspects ; Human ; Human resources ; Humans ; Life Sciences ; Liver - metabolism ; Macaca mulatta ; Medical sciences ; Mice ; Monkeys ; Oral administration ; Pharmacokinetics ; Phenols - blood ; Phenols - metabolism ; Physiological aspects ; Primates ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Review ; Reviews ; Rodents ; Serums ; Species Specificity ; Toxicology ; Various organic compounds
Is Part Of: Environmental health perspectives, 2011-04, Vol.119 (4), p.422-430
Description: Objective: Daily adult human exposure to bisphenol A (BPA) has been estimated at < 1 μg/kg, with virtually complete first-pass conjugation in the liver in primates but not in mice. We measured unconjugated and conjugated BPA levels in serum from adult female rhesus monkeys and adult female mice after oral administration of BPA and compared findings in mice and monkeys with prior published data in women. Methods: Eleven adult female rhesus macaques were fed 400 μg/kg deuterated BPA (dBPA) daily for 7 days. Levels of serum dBPA were analyzed by isotope-dilution liquid chromatography-mass spectrometry (0.2 ng/mL limit of quantitation) over 24 hr on day 1 and on day 7. The same dose of BPA was fed to adult female CD-1 mice; other female mice were administered ³H-BPA at doses ranging from 2 to 100,000 μg/kg. Results: In monkeys, the maximum unconjugated serum dBPA concentration of 4 ng/mL was reached 1 hr after feeding and declined to low levels by 24 hr, with no significant bioaccumulation after seven daily doses. Mice and monkeys cleared unconjugated serum BPA at virtually identical rates. We observed a linear (proportional) relationship between administered dose and serum BPA in mice. Conclusions: BPA pharmacokinetics in women, female monkeys, and mice is very similar. By comparison with approximately 2 ng/mL unconjugated serum BPA reported in multiple human studies, the average 24-hr unconjugated serum BPA concentration of 0.5 ng/mL in both monkeys and mice after a 400 μg/kg oral dose suggests that total daily human exposure is via multiple routes and is much higher than previously assumed.
Publisher: Research Triangle Park, NC: National Institute of Environmental Health Sciences
Language: English
Identifier: ISSN: 0091-6765
EISSN: 1552-9924
DOI: 10.1289/ehp.1002514
PMID: 20855240
CODEN: EVHPAZ
Source: US Government Documents
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Similarity of Bisphenol A Pharmacokinetics in Rhesus Monkeys and Mice: Relevance for Human Exposure

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