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HBcAg特异性辅助性T淋巴细胞22在HBV感染者中的变化和意义
临床肝胆病杂志, 2020-11, Vol.36 (11), p.2435-2440
[Peer Reviewed Journal]
Copyright © Wanfang Data Co. Ltd. All Rights Reserved. ;ISSN: 1001-5256 ;DOI: 10.3969/j.issn.1001-5256.2020.11.008
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Title:
HBcAg特异性辅助性T淋巴细胞22在HBV感染者中的变化和意义
Author:
靳娟
;
黄小正
;
靖新艳
;
张媛
;
尹金玲
;
李佳佳
;
王思思
;
郭雅玲
;
李瑛
Is Part Of:
临床肝胆病杂志, 2020-11, Vol.36 (11), p.2435-2440
Description:
R512.62; 目的 观察HBV感染者中辅助性T淋巴细胞(Th)22、IL-22和转录因子芳香烃受体(AhR)的变化及与临床指标的相关性.方法 选择2018年3月-2019年3月在西安市第八医院就诊的急性乙型肝炎(AHB)患者11例、慢性乙型肝炎(CHB)患者38例和健康对照者(HC)16例,CHB患者使用替诺福韦酯(TDF)抗病毒治疗,收集AHB患者基线和出院6个月后的外周血,收集CHB患者基线、治疗6个月和治疗12个月的外周血,分离外周血单个核细胞(PBMC)和血浆,分别使用佛波酯+伊乌诺霉素和重组HBcAg刺激PBMC,流式细胞术检测非特异性CD3+CD4+IL-22+的Th22和HBcAg特异性Th22.ELISA检测血浆IL-22水平.实时定量PCR检测PBMC中AhR mRNA水平.符合正态分布的计量资料两组间比较采用t检验、配对t检验,多组间比较采用单因素方差分析,进一步两两比较采用LSD-t检验;非正态分布的计量资料多组间比较采用Kruskal-Wallis H检验.计数资料采用χ2检验.采用Spearman相关性分析进行相关性检验.结果 AHB患者非特异性Th22细胞比例(2.86%±0.45%)高于CHB患者(1.39%±0.33%)和HC(0.80%±0.13%),差异均有统计学意义(t值分别为11.80、17.30,P值均<0.001),CHB患者非特异性Th22细胞比例亦高于HC(t=6.825,P<0.001).AHB患者HBcAg特异性Th22细胞比例高于CHB患者(2.97%±0.52%vs 1.22%±0.22%,t=16.58,P<0.001).AHB患者血浆IL-22水平[(130.7±39.97)pg/ml]高于CHB患者[(66.59±20.83)pg/ml]和HC[(50.63±11.07)pg/ml],差异均有统计学意义(t值分别为7.176、7.662,P值均<0.001),CHB患者血浆IL-22水平亦高于HC(t=2.887,P=0.006).AHB患者PBMC中AhR mRNA(11.45±3.03)高于CHB患者(4.81±1.25)和HC(1.10±0.17),差异均有统计学意义(t值分别为10.85、13.75,P值均<0.001),CHB患者AhR mRNA亦高于HC(t=11.77,P<0.001).HBcAg特异性Th22细胞比例在AHB患者和C
Publisher:
西安市第八医院 抗病毒门诊,西安710061%西安市第八医院 医务科,西安710061%西安市第八医院 肝病科,西安710061
Language:
Chinese
Identifier:
ISSN: 1001-5256
DOI: 10.3969/j.issn.1001-5256.2020.11.008
Source:
Alma/SFX Local Collection
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