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Polymorphisms in DNA repair genes: link with biomarkers of the CBMN cytome assay in hospital workers chronically exposed to low doses of ionising radiation

Arhiv za higijenu rada i toksikologiju, 2015-06, Vol.66 (2), p.109-120 [Peer Reviewed Journal]

ISSN: 0004-1254 ;EISSN: 1848-6312 ;DOI: 10.1515/aiht-2015-66-2655 ;PMID: 26110472

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Title:
Polymorphisms in DNA repair genes: link with biomarkers of the CBMN cytome assay in hospital workers chronically exposed to low doses of ionising radiation
Author: Milić, Mirta ; Rozgaj, Ružica ; Kašuba, Vilena ; Jazbec, Ana-Marija ; Starčević, Boris ; Lyzbicki, Barnaba ; Ravegnini, Gloria ; Zenesini, Corrado ; Musti, Muriel ; Hrelia, Patrizia ; Angelini, Sabrina
Subjects: Adult ; Aged ; Biomarkers ; Cytokinesis - genetics ; Cytokinesis - radiation effects ; DNA Damage - genetics ; DNA Damage - radiation effects ; DNA Repair - genetics ; DNA Repair - immunology ; DNA Repair - radiation effects ; Female ; Health Personnel ; Humans ; Male ; Middle Aged ; Occupational Exposure - adverse effects ; Polymorphism, Single Nucleotide ; Radiation Exposure - adverse effects ; Radiation, Ionizing ; Young Adult
Is Part Of: Arhiv za higijenu rada i toksikologiju, 2015-06, Vol.66 (2), p.109-120
Description: Individual sensitivity to ionising radiation (IR) is the result of interaction between exposure, DNA damage, and its repair, which is why polymorphisms in DNA repair genes could play an important role. We examined the association between DNA damage, expressed as micronuclei (MNi), nuclear buds (NBs), and nucleoplasmic bridges (NPBs) and single nucleotide polymorphisms in selected DNA repair genes (APE1, hOGG1, XRCC1, XRCC3, XPD, PARP1, MGMT genes; representative of the different DNA repair pathways operating in mammals) in 77 hospital workers chronically exposed to low doses of IR, and 70 matched controls. A significantly higher MNi frequency was found in the exposed group (16.2±10.4 vs. 11.5±9.4; P=0.003) and the effect appeared to be independent from the principal confounding factor. Exposed individuals with hOGG1, XRCC1, PARP1, and MGMT wild-type alleles or APEX1, as well as XPD (rs13181) heterozygous showed a significantly higher MNi frequency than controls with the same genotypes. Genetic polymorphism analysis and cytogenetic dosimetry have proven to be a powerful tool complementary to physical dosimetry in regular health surveillance programmes.
Publisher: Croatia: Institute for Medical Research and Occupational Health
Language: English;Slovenian;Croatian
Identifier: ISSN: 0004-1254
EISSN: 1848-6312
DOI: 10.1515/aiht-2015-66-2655
PMID: 26110472
Source: DOAJ : Directory of Open Access Journals
AUTh Library subscriptions: ProQuest Central
MEDLINE
Walter De Gruyter: Open Access Journals

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Polymorphisms in DNA repair genes: link with biomarkers of the CBMN cytome assay in hospital workers chronically exposed to low doses of ionising radiation

ISSN: 0004-1254 ;EISSN: 1848-6312 ;DOI: 10.1515/aiht-2015-66-2655 ;PMID: 26110472

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