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Predictive validity of the quick Sequential Organ Failure Assessment (qSOFA) score for the mortality in patients with sepsis in Vietnamese intensive care units

PloS one, 2022-10, Vol.17 (10), p.e0275739-e0275739 [Peer Reviewed Journal]

COPYRIGHT 2022 Public Library of Science ;2022 Do et al 2022 Do et al ;2022 Do et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;ISSN: 1932-6203 ;EISSN: 1932-6203 ;DOI: 10.1371/journal.pone.0275739 ;PMID: 36240177

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Title:
Predictive validity of the quick Sequential Organ Failure Assessment (qSOFA) score for the mortality in patients with sepsis in Vietnamese intensive care units
Author: Do, Son Ngoc ; Luong, Chinh Quoc ; Nguyen, My Ha ; Pham, Dung Thi ; Nguyen, Nga Thi ; Huynh, Dai Quang ; Hoang, Quoc Trong Ai ; Dao, Co Xuan ; Vu, Thang Dinh ; Bui, Ha Nhat ; Nguyen, Hung Tan ; Hoang, Hai Bui ; Le, Thuy Thi Phuong ; Nguyen, Lien Thi Bao ; Duong, Phuoc Thien ; Nguyen, Tuan Dang ; Le, Vuong Hung ; Pham, Giang Thi Tra ; Bui, Tam Van ; Bui, Giang Thi Huong ; Phua, Jason ; Li, Andrew ; Pham, Thao Thi Ngoc ; Nguyen, Chi Van ; Nguyen, Anh Dat
Chu, Dinh-Toi
Subjects: Biology and Life Sciences ; Blood pressure ; Care and treatment ; Clinical trials ; Confidence intervals ; Disease ; Evaluation ; Fatalities ; Hospitals ; Infections ; Intensive care ; Intensive care units ; Logit models ; Medical prognosis ; Medical tests ; Medicine and Health Sciences ; Mortality ; Normal distribution ; Patient outcomes ; Patients ; Physical Sciences ; Regression analysis ; Research and Analysis Methods ; Sensitivity ; Sepsis ; Statistical analysis ; Task forces ; Validity ; Variables
Is Part Of: PloS one, 2022-10, Vol.17 (10), p.e0275739-e0275739
Description: Background The simple scoring systems for predicting the outcome of sepsis in intensive care units (ICUs) are few, especially for limited-resource settings. Therefore, this study aimed to evaluate the accuracy of the quick Sequential (Sepsis-Related) Organ Failure Assessment (qSOFA) score in predicting the mortality of ICU patients with sepsis in Vietnam. Methods We did a multicenter cross-sectional study of patients with sepsis (≥18 years old) presenting to 15 adult ICUs throughout Vietnam on the specified days (i.e., 9th January, 3rd April, 3rd July, and 9th October) representing the different seasons of 2019. The primary and secondary outcomes were the hospital and ICU all-cause mortalities, respectively. The area under the receiver operating characteristic curve (AUROC) was calculated to determine the discriminatory ability of the qSOFA score for deaths in the hospital and ICU. The cut-off value of the qSOFA scores was determined by the receiver operating characteristic curve analysis. Upon ICU admission, factors associated with the hospital and ICU mortalities were assessed in univariable and multivariable logistic models. Results Of 252 patients, 40.1% died in the hospital, and 33.3% died in the ICU. The qSOFA score had a poor discriminatory ability for both the hospital (AUROC: 0.610 [95% CI: 0.538 to 0.681]; cut-off value: ≥2.5; sensitivity: 34.7%; specificity: 84.1%; P AUROC = 0.003) and ICU (AUROC: 0.619 [95% CI: 0.544 to 0.694]; cutoff value: ≥2.5; sensitivity: 36.9%; specificity: 83.3%; P AUROC = 0.002) mortalities. However, multivariable logistic regression analyses show that the qSOFA score of 3 was independently associated with the increased risk of deaths in both the hospital (adjusted odds ratio, AOR: 3.358; 95% confidence interval, CI: 1.756 to 6.422) and the ICU (AOR: 3.060; 95% CI: 1.651 to 5.671). Conclusion In our study, despite having a poor discriminatory value, the qSOFA score seems worthwhile in predicting mortality in ICU patients with sepsis in limited-resource settings. Clinical trial registration Clinical trials registry–India: CTRI/2019/01/016898
Publisher: San Francisco, CA USA: Public Library of Science
Language: English
Identifier: ISSN: 1932-6203
EISSN: 1932-6203
DOI: 10.1371/journal.pone.0275739
PMID: 36240177
Source: GFMER Free Medical Journals
PubMed Central
Public Library of Science (PLoS)
ProQuest Central
DOAJ Directory of Open Access Journals

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Predictive validity of the quick Sequential Organ Failure Assessment (qSOFA) score for the mortality in patients with sepsis in Vietnamese intensive care units

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