skip to main content
Language:
Search Limited to: Search Limited to: Resource type Show Results with: Show Results with: Search type Index

Function and Regulation of Noncanonical Caspase-4/5/11 Inflammasome

The Journal of immunology (1950), 2020-06, Vol.204 (12), p.3063-3069 [Peer Reviewed Journal]

Copyright © 2020 by The American Association of Immunologists, Inc. ;ISSN: 0022-1767 ;EISSN: 1550-6606 ;DOI: 10.4049/jimmunol.2000373 ;PMID: 32513874

Full text available

Citations Cited by
  • Title:
    Function and Regulation of Noncanonical Caspase-4/5/11 Inflammasome
  • Author: Matikainen, Sampsa ; Nyman, Tuula A ; Cypryk, Wojciech
  • Subjects: Animals ; Caspases - metabolism ; Humans ; Inflammasomes - metabolism ; Inflammation - metabolism ; Lipopolysaccharides - metabolism ; Pyroptosis - physiology
  • Is Part Of: The Journal of immunology (1950), 2020-06, Vol.204 (12), p.3063-3069
  • Description: Inflammasomes are multiprotein complexes of the innate immune system that orchestrate development of inflammation by activating the secretion of proinflammatory cytokines, IL-1β and IL-18. The LPS of Gram-negative bacteria have been shown to activate a novel, noncanonical inflammasome by directly binding in the cytosol to human caspase-4 and mouse caspase-11. Activation of noncanonical inflammasome exerts two major effects: it activates the NLRP3-caspase-1-mediated processing and secretion of IL-1β and IL-18 and induces the inflammatory cell death, pyroptosis, via gasdermin D. This previously unexpected cytosolic LPS sensing of the innate immune system provides critical hints for host response to Gram-negative bacterial infections and development of different inflammatory diseases. However, many of its molecular regulatory mechanisms are yet to be discovered. In this review, we provide comprehensive analysis of current understanding of intracellular LPS detection and pyroptosis via noncanonical inflammasome and discuss the recently proposed mechanisms of its function and regulation.
  • Publisher: United States
  • Language: English
  • Identifier: ISSN: 0022-1767
    EISSN: 1550-6606
    DOI: 10.4049/jimmunol.2000373
    PMID: 32513874
  • Source: Freely Accessible Journals
    MEDLINE
    Alma/SFX Local Collection
Back to results list
INSPIRE LIBRARY - TON DUC THANG UNIVERSITY (84-028) 37 755 057 Feedback
19 Nguyen Huu Tho St. Dist.7, HCM thuvien@tdtu.edu.vn

Copyright © 2017 INSPIRE LIBRARY - TON DUC THANG UNIVERSITY

Searching Remote Databases, Please Wait