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Prenatal Phthalate, Perfluoroalkyl Acid, and Organochlorine Exposures and Term Birth Weight in Three Birth Cohorts: Multi-Pollutant Models Based on Elastic Net Regression

Environmental health perspectives, 2016-03, Vol.124 (3), p.365-372 [Peer Reviewed Journal]

COPYRIGHT 2016 National Institute of Environmental Health Sciences ;COPYRIGHT 2016 National Institute of Environmental Health Sciences ;Copyright National Institute of Environmental Health Sciences Mar 2016 ;ISSN: 0091-6765 ;EISSN: 1552-9924 ;DOI: 10.1289/ehp.1408933 ;PMID: 26115335

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Title:
Prenatal Phthalate, Perfluoroalkyl Acid, and Organochlorine Exposures and Term Birth Weight in Three Birth Cohorts: Multi-Pollutant Models Based on Elastic Net Regression
Author: Lenters, Virissa ; Portengen, Lützen ; Rignell-Hydbom, Anna ; Jönsson, Bo A G ; Lindh, Christian H ; Piersma, Aldert H ; Toft, Gunnar ; Bonde, Jens Peter ; Heederik, Dick ; Rylander, Lars ; Vermeulen, Roel
Subjects: Acids ; Adolescent ; Adult ; Arbetsmedicin och miljömedicin ; Biomarkers ; Biomarkers - blood ; Birth size ; Birth weight ; Birth Weight - drug effects ; Caprylates - blood ; Caprylates - toxicity ; Children's Health ; Chromatography ; Cohort Studies ; Dichlorodiphenyl Dichloroethylene - blood ; Dichlorodiphenyl Dichloroethylene - toxicity ; Environmental Health and Occupational Health ; Environmental Pollutants - toxicity ; Europe ; Female ; Fluorocarbons - blood ; Fluorocarbons - toxicity ; Health aspects ; Health risk assessment ; Health Sciences ; Hospitals ; Humans ; Hydrocarbons, Chlorinated - blood ; Hydrocarbons, Chlorinated - toxicity ; Hälsovetenskap ; Infant, Newborn ; Infants (Newborn) ; Linear Models ; Lipids ; Male ; Mass spectrometry ; Maternal Exposure - adverse effects ; Measurement ; Medical and Health Sciences ; Medicin och hälsovetenskap ; Metabolites ; Organochlorine compounds ; Organofluorine compounds ; Pesticides ; Phthalates ; Phthalic Acids - blood ; Phthalic Acids - toxicity ; Polychlorinated Biphenyls - blood ; Polychlorinated Biphenyls - toxicity ; Pregnancy ; Prenatal Exposure Delayed Effects - etiology ; Prenatal Exposure Delayed Effects - physiopathology ; Scientific imaging ; Studies ; Thyroid gland ; Womens health
Is Part Of: Environmental health perspectives, 2016-03, Vol.124 (3), p.365-372
Description: Some legacy and emerging environmental contaminants are suspected risk factors for intrauterine growth restriction. However, the evidence is equivocal, in part due to difficulties in disentangling the effects of mixtures. We assessed associations between multiple correlated biomarkers of environmental exposure and birth weight. We evaluated a cohort of 1,250 term (≥ 37 weeks gestation) singleton infants, born to 513 mothers from Greenland, 180 from Poland, and 557 from Ukraine, who were recruited during antenatal care visits in 2002-2004. Secondary metabolites of diethylhexyl and diisononyl phthalates (DEHP, DiNP), eight perfluoroalkyl acids, and organochlorines (PCB-153 and p,p´-DDE) were quantifiable in 72-100% of maternal serum samples. We assessed associations between exposures and term birth weight, adjusting for co-exposures and covariates, including prepregnancy body mass index. To identify independent associations, we applied the elastic net penalty to linear regression models. Two phthalate metabolites (MEHHP, MOiNP), perfluorooctanoic acid (PFOA), and p,p´-DDE were most consistently predictive of term birth weight based on elastic net penalty regression. In an adjusted, unpenalized regression model of the four exposures, 2-SD increases in natural log-transformed MEHHP, PFOA, and p,p´-DDE were associated with lower birth weight: -87 g (95% CI: -137, -340 per 1.70 ng/mL), -43 g (95% CI: -108, 23 per 1.18 ng/mL), and -135 g (95% CI: -192, -78 per 1.82 ng/g lipid), respectively; and MOiNP was associated with higher birth weight (46 g; 95% CI: -5, 97 per 2.22 ng/mL). This study suggests that several of the environmental contaminants, belonging to three chemical classes, may be independently associated with impaired fetal growth. These results warrant follow-up in other cohorts.
Publisher: United States: National Institute of Environmental Health Sciences
Language: English
Identifier: ISSN: 0091-6765
EISSN: 1552-9924
DOI: 10.1289/ehp.1408933
PMID: 26115335
Source: Open Access: PubMed Central
US Government Documents
DOAJ Directory of Open Access Journals
AUTh Library subscriptions: ProQuest Central
MEDLINE
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Prenatal Phthalate, Perfluoroalkyl Acid, and Organochlorine Exposures and Term Birth Weight in Three Birth Cohorts: Multi-Pollutant Models Based on Elastic Net Regression

COPYRIGHT 2016 National Institute of Environmental Health Sciences ;COPYRIGHT 2016 National Institute of Environmental Health Sciences ;Copyright National Institute of Environmental Health Sciences Mar 2016 ;ISSN: 0091-6765 ;EISSN: 1552-9924 ;DOI: 10.1289/ehp.1408933 ;PMID: 26115335

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