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Associations of Objectively Measured Physical Activity and Sedentary Time with the Risk of Stroke, Myocardial Infarction or All-Cause Mortality in 70-Year-Old Men and Women: A Prospective Cohort Study

Sports medicine (Auckland), 2021-02, Vol.51 (2), p.339-349 [Peer Reviewed Journal]

The Author(s) 2020 ;The Author(s) 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;Copyright Springer Nature B.V. Feb 2021 ;info:eu-repo/semantics/openAccess ;ISSN: 0112-1642 ;ISSN: 2199-1170 ;ISSN: 1179-2035 ;EISSN: 1179-2035 ;EISSN: 2198-9761 ;DOI: 10.1007/s40279-020-01356-y ;PMID: 33063268

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  • Title:
    Associations of Objectively Measured Physical Activity and Sedentary Time with the Risk of Stroke, Myocardial Infarction or All-Cause Mortality in 70-Year-Old Men and Women: A Prospective Cohort Study
  • Author: Ballin, Marcel ; Nordström, Peter ; Niklasson, Johan ; Nordström, Anna
  • Subjects: Accelerometers ; Aging ; Blood pressure ; Cardiovascular disease ; Cardiovascular diseases ; Cerebral infarction ; Exercise ; Heart attacks ; Idrettsmedisinske fag: 850 ; Lifestyles ; Medical disciplines: 700 ; Medicine ; Medicine & Public Health ; Medisinske Fag: 700 ; Mortality ; Myocardial infarction ; Older people ; Original ; Original Research Article ; Physical activity ; Population ; Sports Medicine ; Sports medicine: 850 ; Stroke ; VDP ; Womens health
  • Is Part Of: Sports medicine (Auckland), 2021-02, Vol.51 (2), p.339-349
  • Description: Objective To study the associations of objectively measured physical activity (PA) and sedentary time (ST) with the combined outcome of incident stroke, myocardial infarction (MI) or all-cause mortality in older adults. Methods N  = 3343 men and women aged 70 who participated in a health survey between 2012 and 2017 were included. Actigraph GT3X+ accelerometers were used to measure light-intensity PA (LPA), moderate-intensity PA (MPA) and ST for 1 week. Incident cases of cardiovascular disease (CVD) in terms of stroke or MI, and all-cause mortality were identified using national registers. Hazard ratios (HR) and 95% confidence intervals (CI) were estimated using multivariable-adjusted Cox regressions. Results During a mean follow-up of 2.7 years (0.1–5.6), there were 124 events of CVD or all-cause mortality. After adjusting for potential confounders and mediators, every 30-min/day increment in LPA was associated with 11% lower risk of CVD or all-cause mortality (HR 0.89, 95% CI 0.82–0.97), and every 30-min/day increment in MPA was associated with 36% lower risk (HR 0.64, 95% CI 0.48–0.84). Every 1-h/day increment in ST increased the risk of the outcomes by 33% (HR 1.33, 95% CI 1.14–1.56), although there was no significant association among participants who performed ≥ 30 min/day MPA (HR 1.11, 95% CI 0.82–1.50, P  = 0.034 for interaction). None of the associations were modified by sex ( P  > 0.4 for all). Conclusion Objectively measured LPA and MPA are each associated with lower risk of stroke, MI or all-cause mortality in 70-year-old individuals, while ST is associated with increased risk. The greatest risk reduction is observed for MPA, which also appears to attenuate some of the increased risks associated with ST.
  • Publisher: Cham: Springer International Publishing
  • Language: English;Swedish
  • Identifier: ISSN: 0112-1642
    ISSN: 2199-1170
    ISSN: 1179-2035
    EISSN: 1179-2035
    EISSN: 2198-9761
    DOI: 10.1007/s40279-020-01356-y
    PMID: 33063268
  • Source: Springer Nature OA
    Open Access: PubMed Central
    AUTh Library subscriptions: ProQuest Central
    ROAD
    NORA Norwegian Open Research Archives
    SWEPUB Freely available online
    DOAJ Directory of Open Access Journals
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