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Reduced salience and default mode network activity in women with anorexia nervosa

Journal of psychiatry & neuroscience, 2014-05, Vol.39 (3), p.178-188 [Peer Reviewed Journal]

Canadian Medical Association ;2015 INIST-CNRS ;COPYRIGHT 2014 Joule Inc. ;Copyright Canadian Medical Association May 2014 ;2014 Canadian Medical Association 2014 ;ISSN: 1180-4882 ;EISSN: 1488-2434 ;DOI: 10.1503/jpn.130046 ;PMID: 24280181 ;CODEN: JPNEEF

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Title:
Reduced salience and default mode network activity in women with anorexia nervosa
Author: McFadden, Kristina L., PhD ; Tregellas, Jason R., PhD ; Shott, Megan E., BS ; Frank, Guido K.W., MD
Subjects: Adult ; Adult and adolescent clinical studies ; Anorexia ; Anorexia nervosa ; Anorexia Nervosa - physiopathology ; Biological and medical sciences ; Brain - physiopathology ; Brain Mapping ; Bulimia ; Eating behavior disorders ; Eating disorders ; Female ; Fundamental and applied biological sciences. Psychology ; Health aspects ; Humans ; Magnetic Resonance Imaging ; Medical Education ; Medical research ; Medical sciences ; Medicine, Experimental ; Motor Activity - physiology ; Neural circuitry ; Neural Pathways - physiopathology ; Neuropsychological Tests ; Physiological aspects ; Psychiatry ; Psychoanalysis ; Psychological aspects ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Psychopathology. Psychiatry ; Research Papers ; Reward ; Signal Processing, Computer-Assisted ; Studies ; Women ; Young Adult
Is Part Of: Journal of psychiatry & neuroscience, 2014-05, Vol.39 (3), p.178-188
Description: Background The neurobiology of anorexia nervosa is poorly understood. Neuronal networks contributing to action selection, self-regulation and interoception could contribute to pathologic eating and body perception in people with anorexia nervosa. We tested the hypothesis that the salience network (SN) and default mode network (DMN) would show decreased intrinsic activity in women with anorexia nervosa and those who had recovered from the disease compared to controls. The basal ganglia (BGN) and sensorimotor networks (SMN) were also investigated. Methods Between January 2008 and January 2012, women with restricting-type anorexia nervosa, women who recovered from the disease and healthy control women completed functional magnetic resonance imaging during a conditioned stimulus task. Network activity was studied using independent component analysis. Results We studied 20 women with anorexia nervosa, 24 recovered women and 24 controls. Salience network activity in the anterior cingulate cortex was reduced in women with anorexia nervosa ( p = 0.030; all results false-discovery rate–corrected) and recovered women ( p = 0.039) compared to controls. Default mode network activity in the precuneus was reduced in women with anorexia compared to controls ( p = 0.023). Sensorimotor network activity in the supplementary motor area (SMA; p = 0.008), and the left ( p = 0.028) and right ( p = 0.002) postcentral gyrus was reduced in women with anorexia compared to controls; SMN activity in the SMA ( p = 0.019) and the right postcentral gyrus ( p = 0.008) was reduced in women with anorexia compared to recovered women. There were no group differences in the BGN. Limitations Differences between patient and control populations (e.g., depression, anxiety, medication) are potential confounds, but were included as covariates. Conclusion Reduced SN activity in women with anorexia nervosa and recovered women could be a trait-related biomarker or illness remnant, altering the drive to approach food. The alterations in the DMN and SMN observed only in women with anorexia nervosa suggest state-dependent abnormalities that could be related to altered interoception and body image in these women when they are underweight but that remit following recovery.
Publisher: Ottawa, ON: Canadian Medical Association
Language: French;English
Identifier: ISSN: 1180-4882
EISSN: 1488-2434
DOI: 10.1503/jpn.130046
PMID: 24280181
CODEN: JPNEEF
Source: ProQuest One Psychology
GFMER Free Medical Journals
MEDLINE
PubMed Central
Alma/SFX Local Collection
ProQuest Central

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Reduced salience and default mode network activity in women with anorexia nervosa

Canadian Medical Association ;2015 INIST-CNRS ;COPYRIGHT 2014 Joule Inc. ;Copyright Canadian Medical Association May 2014 ;2014 Canadian Medical Association 2014 ;ISSN: 1180-4882 ;EISSN: 1488-2434 ;DOI: 10.1503/jpn.130046 ;PMID: 24280181 ;CODEN: JPNEEF

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