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The Conserved SOCS Box Motif in Suppressors of Cytokine Signaling Binds to Elongins B and C and May Couple Bound Proteins to Proteasomal Degradation

Proceedings of the National Academy of Sciences - PNAS, 1999-03, Vol.96 (5), p.2071-2076 [Peer Reviewed Journal]

Copyright 1993-1999 The National Academy of Sciences of the United States of America ;Copyright National Academy of Sciences Mar 2, 1999 ;Copyright © 1999, The National Academy of Sciences 1999 ;ISSN: 0027-8424 ;EISSN: 1091-6490 ;DOI: 10.1073/pnas.96.5.2071 ;PMID: 10051596

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Title:
The Conserved SOCS Box Motif in Suppressors of Cytokine Signaling Binds to Elongins B and C and May Couple Bound Proteins to Proteasomal Degradation
Author: Zhang, Jian-Guo ; Farley, Alison ; Nicholson, Sandra E. ; Willson, Tracy A. ; Zugaro, Lisa M. ; Simpson, Richard J. ; Moritz, Robert L. ; Cary, Dale ; Richardson, Rachael ; Hausmann, George ; Kile, Benjamin J. ; Stephen B. H. Kent ; Alexander, Warren S. ; Metcalf, Donald ; Hilton, Douglas J. ; Nicola, Nicos A. ; Baca, Manuel
Subjects: Amino Acid Sequence ; Animals ; Antibodies ; Binding Sites ; Biological Sciences ; Carrier Proteins - chemistry ; Carrier Proteins - metabolism ; Cell Line ; Cell lines ; Cellular biology ; Cysteine Endopeptidases - metabolism ; Cytokines ; Cytokines - physiology ; Elongin ; Gels ; Humans ; Intracellular Signaling Peptides and Proteins ; Mice ; Models, Chemical ; Molecular interactions ; Molecular Sequence Data ; Molecules ; Multienzyme Complexes - metabolism ; Proteasome Endopeptidase Complex ; Protein-Tyrosine Kinases - metabolism ; Proteins ; Proteins - chemistry ; Proteins - metabolism ; Receptors ; Recombinant Fusion Proteins - biosynthesis ; Recombinant Proteins - metabolism ; Repressor Proteins ; Resins ; Signal Transduction ; src Homology Domains ; Suppressor of Cytokine Signaling 1 Protein ; Suppressor of Cytokine Signaling 3 Protein ; Suppressor of Cytokine Signaling Proteins ; Transcription Factors - metabolism ; Transfection ; Tumor Cells, Cultured
Is Part Of: Proceedings of the National Academy of Sciences - PNAS, 1999-03, Vol.96 (5), p.2071-2076
Description: The suppressors of cytokine signaling (SOCS) family of proteins act as intracellular inhibitors of several cytokine signal transduction pathways. Their expression is induced by cytokine activation of the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway and they act as a negative feedback loop by subsequently inhibiting the JAK/STAT pathway either by direct interaction with activated JAKs or with the receptors. These interactions are mediated at least in part by the SH2 domain of SOCS proteins but these proteins also contain a highly conserved C-terminal homology domain termed the SOCS box. Here we show that the SOCS box mediates interactions with elongins B and C, which in turn may couple SOCS proteins and their substrates to the proteasomal protein degradation pathway. Analogous to the family of F-box-containing proteins, it appears that the SOCS proteins may act as adaptor molecules that target activated cell signaling proteins to the protein degradation pathway.
Publisher: United States: National Academy of Sciences of the United States of America
Language: English
Identifier: ISSN: 0027-8424
EISSN: 1091-6490
DOI: 10.1073/pnas.96.5.2071
PMID: 10051596
Source: Geneva Foundation Free Medical Journals at publisher websites
MEDLINE
PubMed Central（OA）

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The Conserved SOCS Box Motif in Suppressors of Cytokine Signaling Binds to Elongins B and C and May Couple Bound Proteins to Proteasomal Degradation

Copyright 1993-1999 The National Academy of Sciences of the United States of America ;Copyright National Academy of Sciences Mar 2, 1999 ;Copyright © 1999, The National Academy of Sciences 1999 ;ISSN: 0027-8424 ;EISSN: 1091-6490 ;DOI: 10.1073/pnas.96.5.2071 ;PMID: 10051596

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