skip to main content
Language:
Search Limited to: Search Limited to: Resource type Show Results with: Show Results with: Search type Index

Efficacy and Toxicity of Folfoxiri for Patients with Metastatic Colorectal Cancer

Open access Macedonian journal of medical sciences, 2019-12, Vol.7 (24), p.4244-4249

Copyright: © 2019 Trinh Le Huy, My Hanh Bui, Toi Chu Dinh, Hoang Thi Hong Xuyen. ;Copyright: © 2019 Trinh Le Huy, My Hanh Bui, Toi Chu Dinh, Hoang Thi Hong Xuyen. 2019 ;ISSN: 1857-9655 ;EISSN: 1857-9655 ;DOI: 10.3889/oamjms.2019.368 ;PMID: 32215071

Full text available

Citations Cited by
  • Title:
    Efficacy and Toxicity of Folfoxiri for Patients with Metastatic Colorectal Cancer
  • Author: Huy, Trinh Le ; Bui, My Hanh ; Dinh, Toi Chu ; Xuyen, Hoang Thi Hong
  • Subjects: Basic and Clinical Medical Researches in Vietnam
  • Is Part Of: Open access Macedonian journal of medical sciences, 2019-12, Vol.7 (24), p.4244-4249
  • Description: In recent times, scientists have found new treatments for colorectal cancer patients. The study is to evaluate the efficacy and toxicity of triplet combination chemotherapy of 5-fluorouracil/leucovorin, oxaliplatin, and irinotecan (FOLFOXIRI) for patients with metastatic colorectal cancer in stage IV. Uncontrolled clinical trial carried on 39 stage IV colorectal cancer patients. The overall response rate of the treatment was 79.4%. The average progression-free survival was 13.4 ± 9 months. The overall survival rate at 12th month and 24th month were 90% and 76%, respectively. The proportion of granulocytopenia was 48.9%, no grade 3 or 4. Side effect beyond hematology was most seen in hepatic toxicity with 52.5%, mainly at grade 1. Vomiting was 18.3%, all at grade 1. Other adverse event was very low at percentage. The triplet combination FOLFOXIRI chemotherapy improves the outcome of patients with metastatic colorectal cancer regarding rate of response, overall survival rate and progression-free survival, and the level of toxicity was acceptable.
  • Publisher: North Macedonia: Republic of Macedonia
  • Language: English
  • Identifier: ISSN: 1857-9655
    EISSN: 1857-9655
    DOI: 10.3889/oamjms.2019.368
    PMID: 32215071
  • Source: PubMed Central (Open access)
    ROAD: Directory of Open Access Scholarly Resources
Back to results list
INSPIRE LIBRARY - TON DUC THANG UNIVERSITY (84-028) 37 755 057 Feedback
19 Nguyen Huu Tho St. Dist.7, HCM thuvien@tdtu.edu.vn

Copyright © 2017 INSPIRE LIBRARY - TON DUC THANG UNIVERSITY

Searching Remote Databases, Please Wait