skip to main content
Language:
Search Limited to: Search Limited to: Resource type Show Results with: Show Results with: Search type Index

Stable Epigenetic Programming of Effector and Central Memory CD4 T Cells Occurs Within 7 Days of Antigen Exposure In Vivo

Frontiers in immunology, 2021-05, Vol.12, p.642807-642807 [Peer Reviewed Journal]

Copyright © 2021 Bevington, Fiancette, Gajdasik, Keane, Soley, Willis, Coleman, Withers and Cockerill. ;Copyright © 2021 Bevington, Fiancette, Gajdasik, Keane, Soley, Willis, Coleman, Withers and Cockerill 2021 Bevington, Fiancette, Gajdasik, Keane, Soley, Willis, Coleman, Withers and Cockerill ;ISSN: 1664-3224 ;EISSN: 1664-3224 ;DOI: 10.3389/fimmu.2021.642807 ;PMID: 34108962

Full text available

Citations Cited by
  • Title:
    Stable Epigenetic Programming of Effector and Central Memory CD4 T Cells Occurs Within 7 Days of Antigen Exposure In Vivo
  • Author: Bevington, Sarah L ; Fiancette, Remi ; Gajdasik, Dominika W ; Keane, Peter ; Soley, Jake K ; Willis, Claire M ; Coleman, Daniel J L ; Withers, David R ; Cockerill, Peter N
  • Subjects: Animals ; Antigens - immunology ; CD4-Positive T-Lymphocytes - immunology ; Epigenesis, Genetic ; epigenetics (chromatin remodelling) ; Gene Regulatory Networks ; Immunologic Memory ; immunological memory responses ; Immunology ; Lymphocyte Activation ; memory T CD4+ cells ; Mice ; Mice, Inbred C57BL ; T cell activation ; Time Factors
  • Is Part Of: Frontiers in immunology, 2021-05, Vol.12, p.642807-642807
  • Description: T cell immunological memory is established within days of an infection, but little is known about the changes in gene regulatory networks accounting for their ability to respond more efficiently to secondary infections. To decipher the timing and nature of immunological memory we performed genome-wide analyses of epigenetic and transcriptional changes in a mouse model generating antigen-specific T cells. Epigenetic reprogramming for Th differentiation and memory T cell formation was already established by the peak of the T cell response after 7 days. The Th memory T cell program was associated with a gain of open chromatin regions, enriched for RUNX, ETS and T-bet motifs, which remained stable for 56 days. The epigenetic programs for both effector memory, associated with T-bet, and central memory, associated with TCF-1, were established in parallel. Memory T cell-specific regulatory elements were associated with greatly enhanced inducible Th1-biased responses during secondary exposures to antigen. Furthermore, memory T cells responded to re-exposure to antigen by rapidly reprograming the entire ETS factor gene regulatory network, by suppressing and activating expression. These data show that gene regulatory networks are epigenetically reprogrammed towards memory during infection, and undergo substantial changes upon re-stimulation.
  • Publisher: Switzerland: Frontiers Media S.A
  • Language: English
  • Identifier: ISSN: 1664-3224
    EISSN: 1664-3224
    DOI: 10.3389/fimmu.2021.642807
    PMID: 34108962
  • Source: Open Access: DOAJ Directory of Open Access Journals
    Open Access: PubMed Central
    Geneva Foundation Free Medical Journals at publisher websites
    MEDLINE
    ROAD: Directory of Open Access Scholarly Resources
Back to results list
INSPIRE LIBRARY - TON DUC THANG UNIVERSITY (84-028) 37 755 057 Feedback
19 Nguyen Huu Tho St. Dist.7, HCM thuvien@tdtu.edu.vn

Copyright © 2017 INSPIRE LIBRARY - TON DUC THANG UNIVERSITY

Searching Remote Databases, Please Wait