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Modulation of innate immunity by Toxoplasma gondii virulence effectors

Nature reviews. Microbiology, 2012-11, Vol.10 (11), p.766-778 [Peer Reviewed Journal]

COPYRIGHT 2012 Nature Publishing Group ;Copyright Nature Publishing Group Nov 2012 ;ISSN: 1740-1526 ;EISSN: 1740-1534 ;DOI: 10.1038/nrmicro2858 ;PMID: 23070557

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Title:
Modulation of innate immunity by Toxoplasma gondii virulence effectors
Author: Hunter, Christopher A ; Sibley, L David
Subjects: Animals ; Animals, Domestic - parasitology ; Cats ; Health aspects ; Host-Parasite Interactions ; Host-parasite relationships ; Humans ; Immune Evasion ; Immunity, Innate ; Immunology ; Mice ; Physiological aspects ; Protein-Tyrosine Kinases - genetics ; Protein-Tyrosine Kinases - metabolism ; Protozoan Proteins - genetics ; Protozoan Proteins - metabolism ; Signal Transduction ; Toxoplasma ; Toxoplasma - genetics ; Toxoplasma - immunology ; Toxoplasma - pathogenicity ; Toxoplasma gondii ; Toxoplasmosis - immunology ; Toxoplasmosis - parasitology ; Toxoplasmosis, Animal - immunology ; Toxoplasmosis, Animal - parasitology ; Virulence (Microbiology) ; Virulence Factors - genetics ; Virulence Factors - metabolism
Is Part Of: Nature reviews. Microbiology, 2012-11, Vol.10 (11), p.766-778
Description: Toxoplasma gondii is a common parasite of animals and humans and can cause serious opportunistic infections. However, the majority of infections are asymptomatic, possibly because the organism has co-evolved with its many vertebrate hosts and has developed multiple strategies to persist asymptomatically for the lifetime of the host. Over the past two decades, infection studies in the mouse, combined with forward-genetics approaches aimed at unravelling the molecular basis of infection, have revealed that T. gondii virulence is mediated, in part, by secretion of effector proteins into the host cell during invasion. Here, we review recent advances that illustrate how these virulence factors disarm innate immunity and promote survival of the parasite.
Publisher: England: Nature Publishing Group
Language: English
Identifier: ISSN: 1740-1526
EISSN: 1740-1534
DOI: 10.1038/nrmicro2858
PMID: 23070557
Source: MEDLINE
ProQuest Central

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Modulation of innate immunity by Toxoplasma gondii virulence effectors

COPYRIGHT 2012 Nature Publishing Group ;Copyright Nature Publishing Group Nov 2012 ;ISSN: 1740-1526 ;EISSN: 1740-1534 ;DOI: 10.1038/nrmicro2858 ;PMID: 23070557

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