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Risk of developing a second primary cancer in male breast cancer survivors: a systematic review and meta-analysis

British journal of cancer, 2022-11, Vol.127 (9), p.1660-1669 [Peer Reviewed Journal]

2022. The Author(s). ;The Author(s) 2022. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;The Author(s) 2022 ;ISSN: 0007-0920 ;EISSN: 1532-1827 ;DOI: 10.1038/s41416-022-01940-1 ;PMID: 36115878

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Title:
Risk of developing a second primary cancer in male breast cancer survivors: a systematic review and meta-analysis
Author: Allen, Isaac ; Hassan, Hend ; Sofianopoulou, Eleni ; Eccles, Diana ; Turnbull, Clare ; Tischkowitz, Marc ; Pharoah, Paul ; Antoniou, Antonis C
Subjects: Breast cancer ; Breast Neoplasms, Male - complications ; Breast Neoplasms, Male - epidemiology ; Colorectal Neoplasms - complications ; Genetic screening ; Humans ; Incidence ; Male ; Mens health ; Meta-analysis ; Middle Aged ; Neoplasms, Second Primary - epidemiology ; Neoplasms, Second Primary - etiology ; Pancreas ; Population studies ; Retrospective Studies ; Risk Factors ; Survivors ; Thyroid ; Thyroid gland
Is Part Of: British journal of cancer, 2022-11, Vol.127 (9), p.1660-1669
Description: With increasing survival after cancer diagnoses, second primary cancers (SPCs) are becoming more prevalent. We investigated the incidence and site of non-breast SPC risks following male breast cancer (BC). PubMed, Embase and Web of Science were systematically searched for studies reporting standardised incidence ratios (SIRs) for SPCs published by March 2022. Meta-analyses used the generic inverse-variance method, assuming a random-effects model. We evaluated SIRs for overall SPCs, site-specific risks, by age at BC onset, time since BC onset and geographic region. We assessed study quality using routine techniques. Eight population-based retrospective cohort studies were identified. SIRs ranged from 1.05 to 2.17. The summary SIR estimate was 1.27 (95% CI: 1.03-1.56, I : 86%), and there were increased colorectal (SIR: 1.29, 95% CI: 1.03-1.61), pancreatic (SIR: 1.64, 95% CI: 1.05-2.55) and thyroid (SIR: 5.58, 95% CI: 1.04-30.05) SPC risks. When an outlying study was excluded, the summary SIR for men diagnosed with BC before age 50 was 1.50 (95% CI: 1.21-1.85), significantly higher than men diagnosed at older ages (SIR: 1.14, 95% CI: 0.98-1.33). Male BC survivors are at elevated risks of developing second primary colorectal, pancreatic and thyroid cancers. The estimates may assist their clinical management and guide decisions on genetic testing.
Publisher: England: Nature Publishing Group
Language: English
Identifier: ISSN: 0007-0920
EISSN: 1532-1827
DOI: 10.1038/s41416-022-01940-1
PMID: 36115878
Source: GFMER Free Medical Journals
MEDLINE
PubMed Central
ProQuest Central

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Risk of developing a second primary cancer in male breast cancer survivors: a systematic review and meta-analysis

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