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FDA-approved medications that impair human spermatogenesis

Oncotarget, 2017-02, Vol.8 (6), p.10714-10725

Copyright: © 2017 Ding et al. 2017 ;ISSN: 1949-2553 ;EISSN: 1949-2553 ;DOI: 10.18632/oncotarget.12956 ;PMID: 27801671

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Title:
FDA-approved medications that impair human spermatogenesis
Author: Ding, Jiayi ; Shang, Xuejun ; Zhang, Zhanhu ; Jing, Hua ; Shao, Jun ; Fei, Qianqian ; Rayburn, Elizabeth R ; Li, Haibo
Subjects: Animals ; Drug Approval ; Drug Labeling ; Fertility - drug effects ; Humans ; Infertility, Male - chemically induced ; Infertility, Male - metabolism ; Infertility, Male - pathology ; Infertility, Male - physiopathology ; Male ; Review ; Risk Assessment ; Risk Factors ; Spermatogenesis - drug effects ; Spermatozoa - drug effects ; Spermatozoa - metabolism ; Spermatozoa - pathology ; United States ; United States Food and Drug Administration
Is Part Of: Oncotarget, 2017-02, Vol.8 (6), p.10714-10725
Description: We herein provide an overview of the single-ingredient U.S. Food and Drug Administration (FDA)-approved drugs that affect human spermatogenesis, potentially resulting in a negative impact on male fertility. To provide this information, we performed an in-depth search of DailyMed, the official website for FDA-approved drug labels. Not surprisingly, hormone-based agents were found to be the drugs most likely to affect human spermatogenesis. The next category of drugs most likely to have effects on spermatogenesis was the antineoplastic agents. Interestingly, the DailyMed labels indicated that several anti-inflammatory drugs affect spermatogenesis, which is not supported by the peer-reviewed literature. Overall, there were a total of 65 labels for drugs of various classes that showed that they have the potential to affect human sperm production and maturation. We identified several drugs indicated to be spermatotoxic in the drug labels that were not reported in the peer-reviewed literature. However, the details about the effects of these drugs on human spermatogenesis are largely lacking, the mechanisms are often unknown, and the clinical impact of many of the findings is currently unclear. Therefore, additional work is needed at both the basic research level and during clinical trials and post-marketing surveillance to fill the gaps in the current knowledge. The present findings will be of interest to physicians and pharmacists, researchers, and those involved in drug development and health care policy.
Publisher: United States: Impact Journals LLC
Language: English
Identifier: ISSN: 1949-2553
EISSN: 1949-2553
DOI: 10.18632/oncotarget.12956
PMID: 27801671
Source: GFMER Free Medical Journals
MEDLINE
PubMed Central
Alma/SFX Local Collection

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FDA-approved medications that impair human spermatogenesis

Copyright: © 2017 Ding et al. 2017 ;ISSN: 1949-2553 ;EISSN: 1949-2553 ;DOI: 10.18632/oncotarget.12956 ;PMID: 27801671

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