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Nephron Patterning: Lessons from Xenopus, Zebrafish, and Mouse Studies

Cells, 2015-09, Vol.4 (3), p.483-499 [Peer Reviewed Journal]

Copyright MDPI AG 2015 ;Distributed under a Creative Commons Attribution 4.0 International License ;2015 by the authors; licensee MDPI, Basel, Switzerland. 2015 ;ISSN: 2073-4409 ;EISSN: 2073-4409 ;DOI: 10.3390/cells4030483 ;PMID: 26378582

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  • Title:
    Nephron Patterning: Lessons from Xenopus, Zebrafish, and Mouse Studies
  • Author: Desgrange, Audrey ; Cereghini, Silvia
  • Subjects: Development Biology ; Life Sciences ; metanephros ; nephron segmentation ; pronephros ; regulatory networks ; Review ; vertebrates
  • Is Part Of: Cells, 2015-09, Vol.4 (3), p.483-499
  • Description: The nephron is the basic structural and functional unit of the vertebrate kidney. To ensure kidney functions, the nephrons possess a highly segmental organization where each segment is specialized for the secretion and reabsorption of particular solutes. During embryogenesis, nephron progenitors undergo a mesenchymal-to-epithelial transition (MET) and acquire different segment-specific cell fates along the proximo-distal axis of the nephron. Even if the morphological changes occurring during nephrogenesis are characterized, the regulatory networks driving nephron segmentation are still poorly understood. Interestingly, several studies have shown that the pronephric nephrons in Xenopus and zebrafish are segmented in a similar fashion as the mouse metanephric nephrons. Here we review functional and molecular aspects of nephron segmentation with a particular interest on the signaling molecules and transcription factors recently implicated in kidney development in these three different vertebrate model organisms. A complete understanding of the mechanisms underlying nephrogenesis in different model organisms will provide novel insights on the etiology of several human renal diseases.
  • Publisher: Switzerland: MDPI AG
  • Language: English
  • Identifier: ISSN: 2073-4409
    EISSN: 2073-4409
    DOI: 10.3390/cells4030483
    PMID: 26378582
  • Source: Open Access: DOAJ Directory of Open Access Journals
    Open Access: PubMed Central
    AUTh Library subscriptions: ProQuest Central
    ROAD: Directory of Open Access Scholarly Resources
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