skip to main content
Language:
Search Limited to: Search Limited to: Resource type Show Results with: Show Results with: Search type Index

Research progress on the pathogenesis of chest tightness variant asthma characterized by chest tightness

Zhejiang da xue xue bao. Journal of Zhejiang University. Medical sciences. Yi xue ban, 2024-04, Vol.53 (2), p.213-220

ISSN: 1008-9292 ;DOI: 10.3724/zdxbyxb-2023-0442 ;PMID: 38310083

Full text available

Citations Cited by
  • Title:
    Research progress on the pathogenesis of chest tightness variant asthma characterized by chest tightness
  • Author: Che, Luanqing ; Lai, Jianxing ; Huang, Huaqiong ; Li, Wen ; Shen, Huahao
  • Subjects: Asthma - physiopathology ; Humans
  • Is Part Of: Zhejiang da xue xue bao. Journal of Zhejiang University. Medical sciences. Yi xue ban, 2024-04, Vol.53 (2), p.213-220
  • Description: Chest tightness variant asthma (CTVA) is an atypical form of asthma with chest tightness as the sole or predominant symptom. The underlying receptors for chest tightness are bronchial C-fibers or rapidly adapting receptors. The nerve impulses are transmitted via the vagus nerve and processed in different regions of the cerebral cortex. Chest tightness is associated with sensory perception, and CTVA patients may have heightened ability to detect subtle changes in lung function, but such sensory perception is unrelated to respiratory muscle activity, lung hyperinflation, or mechanical loading of the respiratory system. Airway inflammation, pulmonary ventilation dysfunction (especially involving small airways), and airway hyperresponsiveness may underlie the sensation of chest tightness. CTVA patients are prone to comorbid anxiety and depression, which share similar central nervous system processing pathways with dyspnea, suggesting a possible neurological basis for the development of CTVA. This article examines the recognition and mechanisms of chest tightness, and explores the pathogenesis of CTVA, focusing on its association with airway inflammation, ventilation dysfunction, airway hyperresponsiveness, and psychosocial factors.
  • Publisher: China
  • Language: English;Chinese
  • Identifier: ISSN: 1008-9292
    DOI: 10.3724/zdxbyxb-2023-0442
    PMID: 38310083
  • Source: Open Access: PubMed Central
    MEDLINE
Back to results list
INSPIRE LIBRARY - TON DUC THANG UNIVERSITY (84-028) 37 755 057 Feedback
19 Nguyen Huu Tho St. Dist.7, HCM thuvien@tdtu.edu.vn

Copyright © 2017 INSPIRE LIBRARY - TON DUC THANG UNIVERSITY

Searching Remote Databases, Please Wait