Language:

Associations of General and Central Adiposity With Incident Diabetes in Chinese Men and Women

Diabetes care, 2018-03, Vol.41 (3), p.494-502 [Peer Reviewed Journal]

2017 by the American Diabetes Association. ;Copyright American Diabetes Association Mar 1, 2018 ;ISSN: 0149-5992 ;EISSN: 1935-5548 ;DOI: 10.2337/dc17-1852 ;PMID: 29298802

Full text available

Citations Cited by

Actions
1. Add to My Research
2. Remove from My Research
3. E-mail
4. Print
5. Permalink
6. Citation
7. EasyBib
8. EndNote
9. RefWorks
10. Delicious
11. Export RIS
12. Export BibTeX

Title:
Associations of General and Central Adiposity With Incident Diabetes in Chinese Men and Women
Author: Bragg, Fiona ; Tang, Kun ; Guo, Yu ; Iona, Andri ; Du, Huaidong ; Holmes, Michael V ; Bian, Zheng ; Kartsonaki, Christiana ; Chen, Yiping ; Yang, Ling ; Sun, Qiang ; Dong, Caixia ; Chen, Junshi ; Collins, Rory ; Peto, Richard ; Li, Liming ; Chen, Zhengming
Subjects: Adipose tissue ; Adiposity ; Adjustment ; Adult ; Adults ; Age ; Aged ; Aged, 80 and over ; Asians - statistics & numerical data ; Body fat ; Body mass ; Body Mass Index ; China - epidemiology ; Diabetes ; Diabetes mellitus ; Diabetes Mellitus - epidemiology ; Female ; Health risks ; Heterogeneity ; Humans ; Male ; Men ; Mens health ; Middle Aged ; Obesity - complications ; Obesity - epidemiology ; Obesity, Abdominal - complications ; Obesity, Abdominal - epidemiology ; Prospective Studies ; Regression analysis ; Research design ; Risk Factors ; Waist Circumference - physiology ; Women ; Womens health ; Young Adult
Is Part Of: Diabetes care, 2018-03, Vol.41 (3), p.494-502
Description: We assess associations of general and central adiposity in middle age and of young adulthood adiposity with incident diabetes in adult Chinese and estimate the associated population burden of diabetes. The prospective China Kadoorie Biobank enrolled 512,891 adults 30-79 years of age from 10 localities across China during 2004-2008. During 9.2 years of follow-up, 13,416 cases of diabetes were recorded among 482,589 participants without diabetes at baseline. Cox regression yielded adjusted hazard ratios (HRs) for incident diabetes associated with measures of general (e.g., BMI and BMI at 25 years) and central (e.g., waist circumference [WC]) adiposity. The mean (SD) BMI was 23.6 kg/m (3.4 kg/m ), and 3.8% had a BMI ≥30 kg/m . Throughout the range examined (19-32 kg/m ), BMI showed a positive log-linear relationship with diabetes, with adjusted HRs per SD higher usual BMI greater in men (1.98; 95% CI 1.93-2.04) than in women (1.77; 1.73-1.81) ( for heterogeneity <0.001). For WC, HRs per SD were 2.13 (95% CI 2.07-2.19) in men and 1.91 (1.87-1.95) in women ( for heterogeneity <0.001). Mutual adjustment attenuated these associations, especially those of BMI. BMI at age 25 years was weakly positively associated with diabetes (men HR 1.09 [95% CI 1.05-1.12]; women 1.04 [1.02-1.07] per SD), which was reversed after adjustment for baseline BMI. In China, the increase in adiposity accounted for ∼50% of the increase in diabetes burden since 1980. Among relatively lean Chinese adults, higher adiposity-general and central-was strongly positively associated with the risk of incident diabetes. The predicted continuing increase in adiposity in China foreshadows escalating rates of diabetes.
Publisher: United States: American Diabetes Association
Language: English
Identifier: ISSN: 0149-5992
EISSN: 1935-5548
DOI: 10.2337/dc17-1852
PMID: 29298802
Source: Geneva Foundation Free Medical Journals at publisher websites
MEDLINE
Alma/SFX Local Collection

Back to results list


INSPIRE LIBRARY - TON DUC THANG UNIVERSITY	(84-028) 37 755 057	Feedback
19 Nguyen Huu Tho St. Dist.7, HCM	thuvien@tdtu.edu.vn	Feedback

Associations of General and Central Adiposity With Incident Diabetes in Chinese Men and Women

2017 by the American Diabetes Association. ;Copyright American Diabetes Association Mar 1, 2018 ;ISSN: 0149-5992 ;EISSN: 1935-5548 ;DOI: 10.2337/dc17-1852 ;PMID: 29298802

Searching Remote Databases, Please Wait