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Genetic Variation in the Gene Encoding Adiponectin Is Associated With an Increased Risk of Type 2 Diabetes in the Japanese Population

Diabetes (New York, N.Y.), 2002-02, Vol.51 (2), p.536-540 [Peer Reviewed Journal]

2002 INIST-CNRS ;COPYRIGHT 2002 American Diabetes Association ;Copyright American Diabetes Association Feb 2002 ;Distributed under a Creative Commons Attribution 4.0 International License ;ISSN: 0012-1797 ;EISSN: 1939-327X ;DOI: 10.2337/diabetes.51.2.536 ;PMID: 11812766 ;CODEN: DIAEAZ

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Title:
Genetic Variation in the Gene Encoding Adiponectin Is Associated With an Increased Risk of Type 2 Diabetes in the Japanese Population
Author: HARA, Kazuo ; BOUTIN, Philippe ; KADOWAKI, Hiroko ; HAGURA, Ryoko ; AKANUMA, Yasuo ; YAZAKI, Yoshio ; NAGAI, Ryozo ; TANIYAMA, Matsuo ; MATSUBARA, Koichi ; YODA, Madoka ; NAKANO, Yasuko ; KIMURA, Satoshi ; MORI, Yasumichi ; TOMITA, Motowo ; ITO, Chikako ; FROGUEL, Philippe ; KADOWAKI, Takashi ; TOBE, Kazuyuki ; DINA, Christian ; YASUDA, Kazuki ; YAMAUCHI, Toshimasa ; OTABE, Shuichi ; OKADA, Terumasa ; ETO, Kazuhiro
Subjects: Adiponectin ; Aged ; Asians - genetics ; Base Sequence - genetics ; Biological and medical sciences ; Biological transport ; Body Mass Index ; Diabetes ; Diabetes mellitus ; Diabetes Mellitus, Type 2 - genetics ; Diabetes Mellitus, Type 2 - pathology ; Diabetes Mellitus, Type 2 - physiopathology ; Female ; Genetic aspects ; Genetic disorders ; Genetic Predisposition to Disease ; Genetic Variation ; Genetics ; Health aspects ; Human genetics ; Humans ; Insulin ; Insulin Resistance - genetics ; Intercellular Signaling Peptides and Proteins ; Japan ; Japanese ; Japanese (Asian people) ; Life Sciences ; Male ; Middle Aged ; Pancreas ; Pancreatic secretions ; Physiological transport ; Polymorphism, Genetic ; Proteins - genetics ; Risk ; Risk factors ; Secretions ; Type 2 diabetes
Is Part Of: Diabetes (New York, N.Y.), 2002-02, Vol.51 (2), p.536-540
Description: Genetic Variation in the Gene Encoding Adiponectin Is Associated With an Increased Risk of Type 2 Diabetes in the Japanese Population Kazuo Hara 1 2 3 , Philippe Boutin 4 , Yasumichi Mori 1 4 , Kazuyuki Tobe 1 2 , Christian Dina 4 , Kazuki Yasuda 5 , Toshimasa Yamauchi 1 2 , Shuichi Otabe 6 , Terumasa Okada 1 5 , Kazuhiro Eto 1 2 , Hiroko Kadowaki 4 , Ryoko Hagura 4 , Yasuo Akanuma 2 4 , Yoshio Yazaki 5 , Ryozo Nagai 7 , Matsuo Taniyama 8 , Koichi Matsubara 9 , Madoka Yoda 10 , Yasuko Nakano 10 , Satoshi Kimura 1 , Motowo Tomita 10 , Satoshi Kimura 1 , Chikako Ito 11 , Philippe Froguel 4 and Takashi Kadowaki 1 2 1 Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo, Japan 2 CREST, Japan Science and Technology Corporation (JST), Tokyo, Japan 3 Institute for Diabetes Care and Research, Asahi Life Foundation, Tokyo, Japan 4 Institute of Biology-Centre National de la Recherche Scientifique (CNRS) 8090, Institute Pasteur de Lille, Lille, France 5 Department of Metabolic Disorder, Research Institute, International Medical Center of Japan, Tokyo, Japan 6 Department of Endocrinology and Metabolism, Kurume University School of Medicine, Kurume, Japan 7 Department of Cardiology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan 8 3rd Department of Internal Medicine, Showa University, Tokyo, Japan 9 Chugai Diagnostics Science, Tokyo, Japan 10 Department of Physiological Chemistry, School of Pharmaceutical Sciences, Showa University, Tokyo, Japan 11 Hiroshima Atomic Bomb Casualty Council Health Management Center, Hiroshima, Japan Abstract An adipocyte-derived peptide, adiponectin (also known as GBP28), is decreased in subjects with type 2 diabetes. Recent genome-wide scans have mapped a diabetes susceptibility locus to chromosome 3q27 , where the adiponectin gene ( APM1 ) is located. Herein, we present evidence of an association between frequent single nucleotide polymorphisms at positions 45 and 276 in the adiponectin gene and type 2 diabetes ( P = 0.003 and P = 0.002, respectively). Subjects with the G/G genotype at position 45 or the G/G genotype at position 276 had a significantly increased risk of type 2 diabetes (odds ratio 1.70 [95% CI 1.09–2.65] and 2.16 [1.22–3.95], respectively) compared with those having the T/T genotype at positions 45 and 276, respectively. In addition, the subjects with the G/G genotype at position 276 had a higher insulin resistance index than those with the T/T genotype (1.61 ± 0.05 vs. 1.19 ± 0.12, P = 0.001). The G allele at position 276 was linearly associated with lower plasma adiponectin levels (G/G: 10.4 ± 0.85 μg/ml, G/T: 13.7 ± 0.87 μg/ml, T/T: 16.6 ± 2.24 μg/ml, P = 0.01) in subjects with higher BMIs. Based on these findings together with the observation that adiponectin improves insulin sensitivity in animal models, we conclude that the adiponectin gene may be a susceptibility gene for type 2 diabetes. Footnotes Address correspondence and reprint requests to Takashi Kadowaki, Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-8655, Japan. E-mail: kadowaki-3im{at}h.u-tokyo.ac.jp . Received for publication 16 February 2001 and accepted in revised form 26 October 2001. Additional information for this article can be found in an online appendix at http://diabetes.diabetesjournals.org . EH, Estimation Haplotype; HOMA, homeostasis model assessment; HOMA-IR, HOMA of insulin resistance; OR, odds ratio; SNP, single nucleotide polymorphism.
Publisher: Alexandria, VA: American Diabetes Association
Language: English
Identifier: ISSN: 0012-1797
EISSN: 1939-327X
DOI: 10.2337/diabetes.51.2.536
PMID: 11812766
CODEN: DIAEAZ
Source: MEDLINE
Alma/SFX Local Collection
ProQuest Central

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Genetic Variation in the Gene Encoding Adiponectin Is Associated With an Increased Risk of Type 2 Diabetes in the Japanese Population

2002 INIST-CNRS ;COPYRIGHT 2002 American Diabetes Association ;Copyright American Diabetes Association Feb 2002 ;Distributed under a Creative Commons Attribution 4.0 International License ;ISSN: 0012-1797 ;EISSN: 1939-327X ;DOI: 10.2337/diabetes.51.2.536 ;PMID: 11812766 ;CODEN: DIAEAZ

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