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Electroimmunology and cardiac arrhythmia

Nature reviews cardiology, 2021-08, Vol.18 (8), p.547-564 [Peer Reviewed Journal]

2021. Springer Nature Limited. ;COPYRIGHT 2021 Nature Publishing Group ;Springer Nature Limited 2021. ;ISSN: 1759-5002 ;EISSN: 1759-5010 ;DOI: 10.1038/s41569-021-00520-9 ;PMID: 33654273

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  • Title:
    Electroimmunology and cardiac arrhythmia
  • Author: Grune, Jana ; Yamazoe, Masahiro ; Nahrendorf, Matthias
  • Subjects: Allergy and Immunology ; Arrhythmia ; Arrhythmias, Cardiac - immunology ; Arrhythmias, Cardiac - physiopathology ; Cardiac arrhythmia ; Cardiovascular research ; Development and progression ; Electrophysiological Phenomena ; Electrophysiology ; Health aspects ; Heart ; Heart conduction system ; Humans ; Immune system ; Immunology ; Leukocytes ; Physiological aspects
  • Is Part Of: Nature reviews cardiology, 2021-08, Vol.18 (8), p.547-564
  • Description: Conduction disorders and arrhythmias remain difficult to treat and are increasingly prevalent owing to the increasing age and body mass of the general population, because both are risk factors for arrhythmia. Many of the underlying conditions that give rise to arrhythmia - including atrial fibrillation and ventricular arrhythmia, which frequently occur in patients with acute myocardial ischaemia or heart failure - can have an inflammatory component. In the past, inflammation was viewed mostly as an epiphenomenon associated with arrhythmia; however, the recently discovered inflammatory and non-canonical functions of cardiac immune cells indicate that leukocytes can be arrhythmogenic either by altering tissue composition or by interacting with cardiomyocytes; for example, by changing their phenotype or perhaps even by directly interfering with conduction. In this Review, we discuss the electrophysiological properties of leukocytes and how these cells relate to conduction in the heart. Given the thematic parallels, we also summarize the interactions between immune cells and neural systems that influence information transfer, extrapolating findings from the field of neuroscience to the heart and defining common themes. We aim to bridge the knowledge gap between electrophysiology and immunology, to promote conceptual connections between these two fields and to explore promising opportunities for future research.
  • Publisher: England: Nature Publishing Group
  • Language: English
  • Identifier: ISSN: 1759-5002
    EISSN: 1759-5010
    DOI: 10.1038/s41569-021-00520-9
    PMID: 33654273
  • Source: MEDLINE
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