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Between inflammation and thrombosis - endothelial cells in COVID-19

European Respiratory Journal, 2021-05, Vol.58 (3), p.2100377 [Peer Reviewed Journal]

2021. This work is licensed under http://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;Copyright ©The authors 2021. 2021 ;ISSN: 0903-1936 ;EISSN: 1399-3003 ;DOI: 10.1183/13993003.00377-2021 ;PMID: 33958433

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  • Title:
    Between inflammation and thrombosis - endothelial cells in COVID-19
  • Author: Birnhuber, Anna ; Fliesser, Elisabeth ; Gorkiewicz, Gregor ; Zacharias, Martin ; Seeliger, Benjamin ; David, Sascha ; Welte, Tobias ; Schmidt, Julius ; Olschewski, Horst ; Wygrecka, Malgorzata ; Kwapiszewska, Grazyna
  • Subjects: Agora
  • Is Part Of: European Respiratory Journal, 2021-05, Vol.58 (3), p.2100377
  • Description: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is causing the current coronavirus disease (COVID-19) pandemic [1]. Over the last months, a plethora of novel research articles has been published, dealing with multiple aspects and manifestations of the disease. Increasing evidence points to a central role of endothelial cells (ECs) in SARS-CoV-2 infection [2–5]. Early studies have already indicated increased expression of vascular and inflammatory factors (such as VCAM-1, IL-8 or MCP-1) in COVID-19 lung tissue [2]. Such markers of endothelial dysfunction and altered endothelial cell integrity are important predictors of a poor outcome in SARS-CoV-2 infections [6], and they are associated with pulmonary edema, intravascular thrombosis and acute respiratory distress syndrome (ARDS).
  • Publisher: England: European Respiratory Society Journals Ltd
  • Language: English
  • Identifier: ISSN: 0903-1936
    EISSN: 1399-3003
    DOI: 10.1183/13993003.00377-2021
    PMID: 33958433
  • Source: Coronavirus Research Database
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