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Probable Pangolin Origin of SARS-CoV-2 Associated with the COVID-19 Outbreak

Current Biology, 2020-04, Vol.30 (7), p.1346-1351.e2 [Peer Reviewed Journal]

2020 Elsevier Inc. ;Copyright © 2020 Elsevier Inc. All rights reserved. ;2020. Not withstanding the ProQuest Terms and Conditions, you may use this content in accordance with the associated terms available at https://www.elsevier.com/legal/elsevier-website-terms-and-conditions ;2020 Elsevier Inc. 2020 Elsevier Inc. ;ISSN: 0960-9822 ;EISSN: 1879-0445 ;DOI: 10.1016/j.cub.2020.03.022 ;PMID: 32197085

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  • Title:
    Probable Pangolin Origin of SARS-CoV-2 Associated with the COVID-19 Outbreak
  • Author: Zhang, Tao ; Wu, Qunfu ; Zhang, Zhigang
  • Subjects: Amino Acid Sequence ; Animals ; Betacoronavirus - genetics ; Betacoronavirus - isolation & purification ; Chiroptera ; Coronavirus Infections - virology ; COVID-19 ; Disease Reservoirs - virology ; Eutheria - virology ; Genome, Viral ; Malaysia ; origin ; Pandemics ; pangolin ; Phylogeny ; Pneumonia, Viral - virology ; SARS-CoV-2 ; Sequence Alignment ; Spike Glycoprotein, Coronavirus - chemistry
  • Is Part Of: Current Biology, 2020-04, Vol.30 (7), p.1346-1351.e2
  • Description: An outbreak of coronavirus disease 2019 (COVID-19) caused by the 2019 novel coronavirus (SARS-CoV-2) began in the city of Wuhan in China and has widely spread worldwide. Currently, it is vital to explore potential intermediate hosts of SARS-CoV-2 to control COVID-19 spread. Therefore, we reinvestigated published data from pangolin lung samples from which SARS-CoV-like CoVs were detected by Liu et al. [1]. We found genomic and evolutionary evidence of the occurrence of a SARS-CoV-2-like CoV (named Pangolin-CoV) in dead Malayan pangolins. Pangolin-CoV is 91.02% and 90.55% identical to SARS-CoV-2 and BatCoV RaTG13, respectively, at the whole-genome level. Aside from RaTG13, Pangolin-CoV is the most closely related CoV to SARS-CoV-2. The S1 protein of Pangolin-CoV is much more closely related to SARS-CoV-2 than to RaTG13. Five key amino acid residues involved in the interaction with human ACE2 are completely consistent between Pangolin-CoV and SARS-CoV-2, but four amino acid mutations are present in RaTG13. Both Pangolin-CoV and RaTG13 lost the putative furin recognition sequence motif at S1/S2 cleavage site that can be observed in the SARS-CoV-2. Conclusively, this study suggests that pangolin species are a natural reservoir of SARS-CoV-2-like CoVs. [Display omitted] •Pangolin-CoV is 91.02% identical to SARS-CoV-2 at the whole-genome level•Pangolin-CoV is the second closest relative of SARS-CoV-2 behind RaTG13•Five key amino acids in the RBD are consistent between Pangolin-CoV and SARS-CoV-2•Only SARS-CoV-2 contains a potential cleavage site for furin proteases The emerging SARS-coronavirus 2 (SARS-CoV-2) poses tremendous threat to human health. Zhang, Wu et al. show that like bats, pangolin species are a natural reservoir of SARS-CoV-2-like CoVs. This finding might help to find the intermediate host of SARS-CoV-2 for blocking a global coronavirus pandemic.
  • Publisher: England: Elsevier Inc
  • Language: English
  • Identifier: ISSN: 0960-9822
    EISSN: 1879-0445
    DOI: 10.1016/j.cub.2020.03.022
    PMID: 32197085
  • Source: Coronavirus Research Database
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