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Secondary Infections in Hospitalized COVID-19 Patients: Indian Experience

Infection and drug resistance, 2021-01, Vol.14, p.1893-1903 [Peer Reviewed Journal]

2021 Vijay et al. ;COPYRIGHT 2021 Dove Medical Press Limited ;2021. This work is licensed under https://creativecommons.org/licenses/by-nc/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;2021 Vijay et al. 2021 Vijay et al. ;ISSN: 1178-6973 ;EISSN: 1178-6973 ;DOI: 10.2147/idr.s299774 ;PMID: 34079300

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Title:
Secondary Infections in Hospitalized COVID-19 Patients: Indian Experience
Author: Vijay, Sonam ; Bansal, Nitin ; Rao, Brijendra Kumar ; Veeraraghavan, Balaji ; Rodrigues, Camilla ; Wattal, Chand ; Goyal, Jagdish Prasad ; Tadepalli, Karuna ; Mathur, Purva ; Venkateswaran, Ramanathan ; Venkatasubramanian, Ramasubramanian ; Khadanga, Sagar ; Bhattacharya, Sanjay ; Mukherjee, Sudipta ; Baveja, Sujata ; Sistla, Sujatha ; Panda, Samiran ; Walia, Kamini
Subjects: antibiotics ; Antifungal agents ; Antimicrobial agents ; Antimicrobial resistance ; Bacterial infections ; Bacterial pneumonia ; Coronaviruses ; COVID-19 ; Development and progression ; Drug resistance ; Drug resistance in microorganisms ; Gram-negative bacteria ; Health aspects ; hospital acquired infections ; Hospital patients ; Hospitals ; India ; Intensive care units ; Klebsiella pneumoniae ; Medical research ; Medicine, Experimental ; Mortality ; Original Research ; Pathogens ; Patients ; Pneumonia ; Prevalence studies (Epidemiology) ; secondary infections
Is Part Of: Infection and drug resistance, 2021-01, Vol.14, p.1893-1903
Description: Critically ill coronavirus disease 2019 (COVID-19) patients need hospitalization which increases their risk of acquiring secondary bacterial and fungal infections. The practice of empiric antimicrobial prescription, due to limited diagnostic capabilities of many hospitals, has the potential to escalate an already worrisome antimicrobial resistance (AMR) situation in India. This study reports the prevalence and profiles of secondary infections (SIs) and clinical outcomes in hospitalized COVID-19 patients in India. A retrospective study of secondary infections in patients admitted in intensive care units (ICUs) and wards of ten hospitals of the Indian Council of Medical Research (ICMR) AMR surveillance network, between June and August 2020, was undertaken. The demographic data, time of infection after admission, microbiological and antimicrobial resistance data of secondary infections, and clinical outcome data of the admitted COVID-19 patients were collated. Out of 17,534 admitted patients, 3.6% of patients developed secondary bacterial or fungal infections. The mortality among patients who developed secondary infections was 56.7% against an overall mortality of 10.6% in total admitted COVID-19 patients. Gram-negative bacteria were isolated from 78% of patients. (29%) was the predominant pathogen, followed by (21%). Thirty-five percent of patients reported polymicrobial infections, including fungal infections. High levels of carbapenem resistance was seen in (92.6%) followed by (72.8%). Predominance of Gram-negative pathogens in COVID-19 patients coupled with high rates of resistance to higher generation antimicrobials is an alarming finding. A high rate of mortality in patients with secondary infections warrants extra caution to improve the infection control practices and practice of antimicrobial stewardship interventions not only to save patient lives but also prevent selection of drug-resistant infections, to which the current situation is very conducive.
Publisher: New Zealand: Dove Medical Press Limited
Language: English
Identifier: ISSN: 1178-6973
EISSN: 1178-6973
DOI: 10.2147/idr.s299774
PMID: 34079300
Source: GFMER Free Medical Journals
PubMed Central
DOVE Medical Press Journals
Coronavirus Research Database
ROAD: Directory of Open Access Scholarly Resources
ProQuest Central
DOAJ Directory of Open Access Journals

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Secondary Infections in Hospitalized COVID-19 Patients: Indian Experience

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