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Cumulative psychological stress and cardiovascular disease risk in middle aged and older women: Rationale, design, and baseline characteristics

The American heart journal, 2017-10, Vol.192, p.1-12 [Peer Reviewed Journal]

2017 Elsevier Inc. ;Copyright © 2017 Elsevier Inc. All rights reserved. ;Copyright Elsevier Limited Oct 1, 2017 ;ISSN: 0002-8703 ;EISSN: 1097-6744 ;DOI: 10.1016/j.ahj.2017.06.012 ;PMID: 28938955

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Title:
Cumulative psychological stress and cardiovascular disease risk in middle aged and older women: Rationale, design, and baseline characteristics
Author: Albert, Michelle A. ; Durazo, Eva M. ; Slopen, Natalie ; Zaslavsky, Alan M. ; Buring, Julie E. ; Silva, Ted ; Chasman, Daniel ; Williams, David R.
Subjects: Aging ; Anxiety ; Cardiovascular disease ; Cardiovascular diseases ; Cardiovascular Diseases - epidemiology ; Cardiovascular Diseases - etiology ; Cardiovascular Diseases - psychology ; Cerebral infarction ; Diabetes mellitus ; Female ; Genetic factors ; Global Health ; Health risks ; Humans ; Mental depression ; Middle age ; Middle Aged ; Minority & ethnic groups ; Morbidity - trends ; Mortality ; Myocardial infarction ; Older people ; Psychological stress ; Psychology ; Randomized Controlled Trials as Topic - methods ; Risk ; Risk Assessment - methods ; Risk Factors ; Sleep ; Smoking ; Social interactions ; Socioeconomic factors ; Stress, Psychological - complications ; Women's Health ; Womens health
Is Part Of: The American heart journal, 2017-10, Vol.192, p.1-12
Description: Although a growing body of evidence indicates strong links between psychological stress (stress) and untoward cardiovascular disease (CVD) outcomes, comprehensive examination of these effects remains lacking. The “Cumulative Psychological Stress and Cardiovascular Disease Risk in Middle Aged and Older Women” study is embedded within the landmark Women's Health Study (WHS) follow-up cohort and seeks to evaluate the individual and joint effects of stressors (cumulative stress) on incident CVD risk, including myocardial infarction, stroke, coronary revascularization and CVD death. GWAS data will be used for exploratory analyses to identify any genes associated with stress and CVD. This study prospectively follows 25,335 women (mean age 72.2 ± 6.04 years) without CVD who returned a short mailed stress questionnaire at baseline and 3 years of follow-up inquiring about their experiences with stress including perceived stress, work stress, work-family spillover, financial stress, traumatic and major life events, discrimination and neighborhood environment/stressors. Other domains ascertained were sleep, anger, cynical hostility, depression, anxiety, social support, intimate partner relations, and volunteer and social activities. Higher levels of cumulative stress were associated with younger age and black race/ethnicity, divorced or separated marital status, increased prevalence of obesity, smoking, diabetes, depression and anxiety (p<0.001 for each). Findings from this study will provide clinically important, new information about associations of cumulative stress, environmental, lifestyle and genetic factors with incident CVD risk in aging women.
Publisher: United States: Elsevier Inc
Language: English
Identifier: ISSN: 0002-8703
EISSN: 1097-6744
DOI: 10.1016/j.ahj.2017.06.012
PMID: 28938955
Source: MEDLINE
ProQuest Central

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Cumulative psychological stress and cardiovascular disease risk in middle aged and older women: Rationale, design, and baseline characteristics

2017 Elsevier Inc. ;Copyright © 2017 Elsevier Inc. All rights reserved. ;Copyright Elsevier Limited Oct 1, 2017 ;ISSN: 0002-8703 ;EISSN: 1097-6744 ;DOI: 10.1016/j.ahj.2017.06.012 ;PMID: 28938955

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