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Relation between serum cathepsin D levels and endothelial dysfunction in patients with chronic kidney disease

Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia, 2015, Vol.35 (1), p.72-79 [Peer Reviewed Journal]

This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 International License. ;ISSN: 1989-2284 ;EISSN: 1989-2284 ;DOI: 10.3265/Nefrologia.pre2014.Oct.12609 ;PMID: 25611836

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Title:
Relation between serum cathepsin D levels and endothelial dysfunction in patients with chronic kidney disease
Author: Ozkayar, Nihal ; Piskinpasa, Serhan ; Akyel, Fatma ; Turgut, Didem ; Bulut, Mesudiye ; Turhan, Turan ; Dede, Fatih
Subjects: Adult ; Aged ; Atherosclerosis - blood ; Atherosclerosis - physiopathology ; Brachial Artery ; Cathepsin D - blood ; Cathepsin D - physiology ; Creatinine - blood ; Endothelium, Vascular - physiopathology ; Female ; Glomerular Filtration Rate ; Humans ; Male ; Middle Aged ; Prospective Studies ; Renal Insufficiency, Chronic - blood ; Renal Insufficiency, Chronic - physiopathology ; Urology & Nephrology ; Vasodilation
Is Part Of: Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia, 2015, Vol.35 (1), p.72-79
Description: We aimed to investigate the role of cathepsin D, an inflammatory and atherosclerotic mediator, in endothelial dysfunction in chronic kidney disease. The study included 65 patients with stage 2-4 chronic kidney disease (35 females, 30 males; mean age, 55.8±15.6 years). Serum creatinine and cathepsin D levels and glomerular filtration rates (GFRs) were determined, and brachial flow-mediated dilation (FMD) percentage was measured by two-dimensional gray scale and color flow Doppler and vascular imaging. FMD ≤6% was considered to indicate endothelial dysfunction. Mean GFR, median creatinine levels, and median cathepsin D levels were 40.2±11.2mL/min/1.73m2, 1.7mg/dL, and 819.75ng/mL, respectively. Endothelial dysfunction was present in 30 of the 65 patients (46.2%). There was a significant difference between groups with and without endothelial dysfunction in terms of cathepsin D (p=0.001) and creatinine (p=0.03) levels, and negative and significant correlations were found between brachial artery FMD% and cathepsin D (r=−0.359, p=0.003) and creatinine (r=−0.304, p=0.014) levels. Cathepsin D, which is known to be associated with atherosclerosis, may play a role in the process of endothelial dysfunction. Further studies are essential to determine the exact function of cathepsin D in endothelial dysfunction in chronic kidney disease and to determine its value as a tool for early diagnosis and target for treatment of cardiovascular diseases in patients with chronic kidney disease.
Publisher: Spain: Sociedad Española de Nefrología
Language: English;Spanish;Portuguese
Identifier: ISSN: 1989-2284
EISSN: 1989-2284
DOI: 10.3265/Nefrologia.pre2014.Oct.12609
PMID: 25611836
Source: SciELO
MEDLINE
Alma/SFX Local Collection

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Relation between serum cathepsin D levels and endothelial dysfunction in patients with chronic kidney disease

This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 International License. ;ISSN: 1989-2284 ;EISSN: 1989-2284 ;DOI: 10.3265/Nefrologia.pre2014.Oct.12609 ;PMID: 25611836

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