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Ischemic index changes in diabetic retinopathy after intravitreal dexamethasone implant using ultra-widefield fluorescein angiography: a pilot study

Acta diabetologica, 2017-08, Vol.54 (8), p.769-773 [Peer Reviewed Journal]

Springer-Verlag Italia 2017 ;ISSN: 0940-5429 ;EISSN: 1432-5233 ;DOI: 10.1007/s00592-017-1010-1 ;PMID: 28577137

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Title:
Ischemic index changes in diabetic retinopathy after intravitreal dexamethasone implant using ultra-widefield fluorescein angiography: a pilot study
Author: Querques, Lea ; Parravano, Mariacristina ; Sacconi, Riccardo ; Rabiolo, Alessandro ; Bandello, Francesco ; Querques, Giuseppe
Subjects: Acuity ; Age ; Aged ; Angiography ; Clinical outcomes ; Dexamethasone ; Dexamethasone - administration & dosage ; Diabetes ; Diabetes mellitus ; Diabetic retinopathy ; Diabetic Retinopathy - diagnostic imaging ; Diabetic Retinopathy - drug therapy ; Diabetic Retinopathy - physiopathology ; Drug delivery systems ; Drug Implants - administration & dosage ; Edema ; Female ; Fluorescein ; Fluorescein Angiography ; Humans ; Injection ; Internal Medicine ; Ischemia ; Macular Edema - diagnostic imaging ; Macular Edema - drug therapy ; Macular Edema - physiopathology ; Male ; Medical imaging ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Middle Aged ; Original Article ; Pilot Projects ; Prospective Studies ; Retina ; Retina - drug effects ; Retina - physiopathology ; Retinography ; Retinopathy ; Steroids ; Tomography, Optical Coherence ; Visual Acuity
Is Part Of: Acta diabetologica, 2017-08, Vol.54 (8), p.769-773
Description: Aims To investigate the effect of dexamethasone intravitreal implant on peripheral ischemia in patients affected by diabetic macular edema (DME). Methods Patients with treatment-naïve diabetic retinopathy (DR) undergoing intravitreal dexamethasone implant for DME between October 2015 and March 2017 were enrolled. Patients underwent a comprehensive ocular examination at baseline (<2 weeks before treatment) and 10 ± 2 weeks after dexamethasone implant including best-corrected visual acuity (BCVA), intraocular pressure, optical coherence tomography, ultra-widefield (UWF) retinography and UWF fluorescein angiography (UWFA). Results Nine eyes of seven consecutive patients (five males; mean age 66.4 ± 6.7 years) were enrolled. Mean duration of DR was 12.3 ± 8.4 years. Mean interval between UWFA acquisitions was 12.1 ± 2.1 weeks, and the mean interval between intravitreal injection and UWFA acquisition was 11.0 ± 1.6 weeks. Mean pre- and post-injection BCVA was 0.30 ± 0.20 and 0.21 ± 0.14 logMAR ( p = 0.06), respectively. Mean pre- and post-injection central macular thickness was 449.8 ± 92.5 and 356.3 ± 52.4 μm ( p = 0.03), respectively. Mean pre- and post-injection ischemic index was 24.0 ± 25.0 and 9.8 ± 12.1% ( p = 0.0427), respectively. Conclusions Intravitreal dexamethasone implant reduces peripheral retina ischemia in patients with DR.
Publisher: Milan: Springer Milan
Language: English
Identifier: ISSN: 0940-5429
EISSN: 1432-5233
DOI: 10.1007/s00592-017-1010-1
PMID: 28577137
Source: MEDLINE
ProQuest Central

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Ischemic index changes in diabetic retinopathy after intravitreal dexamethasone implant using ultra-widefield fluorescein angiography: a pilot study

Springer-Verlag Italia 2017 ;ISSN: 0940-5429 ;EISSN: 1432-5233 ;DOI: 10.1007/s00592-017-1010-1 ;PMID: 28577137

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