Language:

TGFβ signalling in context

Nature reviews. Molecular cell biology, 2012-10, Vol.13 (10), p.616-630 [Peer Reviewed Journal]

Full text available

Citations Cited by

Title:
TGFβ signalling in context
Author: Massague, Joan
Subjects: Animals ; Cell Membrane - metabolism ; Cell Nucleus - metabolism ; Chromatin - metabolism ; Embryonic development ; Epithelial-Mesenchymal Transition ; Genetic aspects ; Humans ; Neoplasms - metabolism ; Observations ; Phosphorylation ; Receptors, Transforming Growth Factor beta - metabolism ; Signal Transduction ; Smad Proteins - metabolism ; Transforming Growth Factor beta - metabolism ; Transforming growth factors
Is Part Of: Nature reviews. Molecular cell biology, 2012-10, Vol.13 (10), p.616-630
Description: The basic elements of the transforming growth factor-β (TGFβ) pathway were revealed more than a decade ago. Since then, the concept of how the TGFβ signal travels from the membrane to the nucleus has been enriched with additional findings, and its multifunctional nature and medical relevance have relentlessly come to light. However, an old mystery has endured: how does the context determine the cellular response to TGFβ? Solving this question is key to understanding TGFβ biology and its many malfunctions. Recent progress is pointing at answers.
Publisher: England: Nature Publishing Group
Language: English
Identifier: ISSN: 1471-0072
EISSN: 1471-0080
DOI: 10.1038/nrm3434
PMID: 22992590
Source: MEDLINE
ProQuest Central

Back to results list


INSPIRE LIBRARY - TON DUC THANG UNIVERSITY	(84-028) 37 755 057	Feedback
19 Nguyen Huu Tho St. Dist.7, HCM	thuvien@tdtu.edu.vn	Feedback

Searching Remote Databases, Please Wait