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Clinical Characteristics and Outcomes of COVID‐19 in Solid Organ Transplant Recipients: A Case‐Control Study

American Journal of Transplantation, 2020-11 [Peer Reviewed Journal]

2020. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the associated terms available at https://novel-coronavirus.onlinelibrary.wiley.com ;DOI: 10.1111/ajt.16188

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  • Title:
    Clinical Characteristics and Outcomes of COVID‐19 in Solid Organ Transplant Recipients: A Case‐Control Study
  • Author: Chaudhry, Zohra S ; Williams, Jonathan D ; Vahia, Amit ; Fadel, Raef ; Tommy Parraga Acosta ; Prashar, Rohini ; Shrivastava, Pritika ; Khoury, Nadeen ; Julio Pinto Corrales ; Williams, Celeste ; Nagai, Shunji ; Abouljoud, Marwan ; Milagros Samaniego‐Picota ; Odaliz Abreu Lanfranco ; Ramon del Busto ; Ramesh, Mayur S ; Patel, Anita ; Alangaden, George J
  • Is Part Of: American Journal of Transplantation, 2020-11
  • Description: Solid organ transplant recipients (SOTr) with COVID‐19 are expected to have poorer outcomes compared to non‐transplant patients due to immunosuppression and comorbidities. The clinical characteristics of 47 SOTr (38 kidneys and 9 non‐kidney organs) were compared to 100 consecutive hospitalized non‐transplant controls. 12/47 SOTr managed as outpatients were subsequently excluded from the outcome analyses to avoid potential selection bias. Chronic kidney disease (89% vs. 57% p=0.0007), diabetes (66% vs. 33% p=0.0007), and hypertension (94% vs. 72% p=0.006) were more common in the 35 hospitalized SOTr compared to controls. Diarrhea (54% vs. 17%, p<0.0001) was more frequent in SOTr. Primary composite outcome (escalation to ICU, mechanical ventilation, or in‐hospital all‐cause mortality) was comparable between SOTr and controls (40% vs. 48%, OR 0.72 CI [0.33‐1.58] p=0.42), despite more comorbidities in SOTr. Acute kidney injury (AKI) requiring renal replacement therapy occurred in 20% of SOTr compared to 4% of controls (OR 6 CI [1.64‐22] p=0.007). Multivariate analysis demonstrated that increasing age and clinical severity was associated with mortality. Transplant status itself was not associated with mortality.
  • Publisher: Hoboken: John Wiley & Sons, Inc
  • Language: English
  • Identifier: DOI: 10.1111/ajt.16188
  • Source: Coronavirus Research Database
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