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Association Between Serum Klotho and Chronic Obstructive Pulmonary Disease in US Middle-Aged and Older Individuals: A Cross-Sectional Study from NHANES 2013-2016

International journal of chronic obstructive pulmonary disease, 2024-01, Vol.19, p.543-553 [Peer Reviewed Journal]

2024 Shi et al. ;COPYRIGHT 2024 Dove Medical Press Limited ;ISSN: 1178-2005 ;EISSN: 1178-2005 ;DOI: 10.2147/COPD.S451859 ;PMID: 38435124

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  • Title:
    Association Between Serum Klotho and Chronic Obstructive Pulmonary Disease in US Middle-Aged and Older Individuals: A Cross-Sectional Study from NHANES 2013-2016
  • Author: Shi, Yushan ; Xu, Zhangmeng ; Pu, Shuangshuang ; Xu, Kanghong ; Wang, Yanan ; Zhang, Chunlai
  • Subjects: Adult ; Aged ; Analysis ; chronic obstructive pulmonary disease ; Cross-Sectional Studies ; cross-sectional study ; Female ; Health surveys ; Humans ; Lung diseases ; Male ; Medical research ; Medicine, Experimental ; Middle Aged ; national health and nutrition survey ; nhanes ; Nutrition Surveys ; Odds Ratio ; Pulmonary Disease, Chronic Obstructive - diagnosis ; Pulmonary Disease, Chronic Obstructive - epidemiology ; Surveys ; α-klotho (klotho)
  • Is Part Of: International journal of chronic obstructive pulmonary disease, 2024-01, Vol.19, p.543-553
  • Description: This study sought to examine the potential association between serum Klotho levels and the prevalence of COPD in the United States. This study was a cross-sectional analysis involving 4361 adults aged 40-79 years participating in the US National Health and Nutrition Examination Survey (NHANES) conducted between 2013 and 2016. Our investigation utilized multivariate logistic regression and restricted cubic spline (RCS) regression to explore the potential correlation between serum Klotho concentrations and the prevalence of COPD. Additionally, we conducted stratified and interaction analyses to evaluate the consistency and potential modifiers of this relationship. In this study encompassing 4631 patients (with an average age of 57.6 years, 47.5% of whom were male), 445 individuals (10.2%) were identified as having COPD. In the fully adjusted model, ln-transformed serum Klotho was negatively associated with COPD (OR = 0.71; 95% CI: 0.51-0.99; p = 0.043). Meanwhile, compared with quartile 1, serum Klotho levels in quartiles 2-4 yielded odds ratios (ORs) (95% CI) for COPD were 0.84 (0.63~1.11), 0.76 (0.56~1.02), 0.84 (0.62~1.13), respectively. A negative relationship was observed between the ln-transformed serum Klotho and occurrence of COPD (nonlinear: p = 0.140). the association between ln-transformed serum Klotho and COPD were stable in stratified analyses. Serum Klotho was negatively associated with the incidence of COPD, when ln-transformed Klotho concentration increased by 1 unit, the risk of COPD was 29% lower.
  • Publisher: New Zealand: Dove Medical Press Limited
  • Language: English
  • Identifier: ISSN: 1178-2005
    EISSN: 1178-2005
    DOI: 10.2147/COPD.S451859
    PMID: 38435124
  • Source: GFMER Free Medical Journals
    MEDLINE
    PubMed Central
    DOVE Medical Press Journals
    ProQuest Central
    DOAJ Directory of Open Access Journals
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