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Evidence of Artemisinin-Resistant Malaria in Africa

The New England journal of medicine, 2021-09, Vol.385 (13), p.1163-1171 [Peer Reviewed Journal]

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Title:
Evidence of Artemisinin-Resistant Malaria in Africa
Author: Balikagala, Betty ; Fukuda, Naoyuki ; Ikeda, Mie ; Katuro, Osbert T ; Tachibana, Shin-Ichiro ; Yamauchi, Masato ; Opio, Walter ; Emoto, Sakurako ; Anywar, Denis A ; Kimura, Eisaku ; Palacpac, Nirianne M.Q ; Odongo-Aginya, Emmanuel I ; Ogwang, Martin ; Horii, Toshihiro ; Mita, Toshihiro
Subjects: Alleles ; Artemisinin ; Artesunate ; Consent ; Distribution ; Drug dosages ; Drug resistance in microorganisms ; Genetic aspects ; Genomes ; Global Health ; Infectious Disease ; Intravenous administration ; Malaria ; Medical research ; Medicine, Experimental ; Mutation ; Parasite resistance ; Parasites ; Parasitic Infections ; Patients ; Plasmodium falciparum ; Proteins ; Single-nucleotide polymorphism ; Survival
Is Part Of: The New England journal of medicine, 2021-09, Vol.385 (13), p.1163-1171
Description: Artemisinin compounds are the backbone of global malaria treatment strategies, but resistant strains are emerging in Southeast Asia. In this report, the investigators report the emergence of artemisinin-resistant Plasmodium falciparum strains in Northern Uganda, with the predominant mutations observed in the kelch13 gene.
Publisher: Boston: Massachusetts Medical Society
Language: English
Identifier: ISSN: 0028-4793
EISSN: 1533-4406
DOI: 10.1056/NEJMoa2101746
Source: ProQuest One Psychology
AUTh Library subscriptions: ProQuest Central

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