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Impact of anthropometric parameters on outcomes in Asians with metabolic dysfunction‐associated fatty liver disease

Journal of cachexia, sarcopenia and muscle, 2023-12, Vol.14 (6), p.2747-2756 [Peer Reviewed Journal]

2023 The Authors. Journal of Cachexia, Sarcopenia and Muscle published by Wiley Periodicals LLC. ;2023. This work is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;ISSN: 2190-5991 ;EISSN: 2190-6009 ;DOI: 10.1002/jcsm.13351 ;PMID: 37881112

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Title:
Impact of anthropometric parameters on outcomes in Asians with metabolic dysfunction‐associated fatty liver disease
Author: Choi, Kyu Yeon ; Kim, Tae Yeon ; Chon, Young Eun ; Kim, Mi Na ; Lee, Joo Ho ; Hwang, Seong Gyu ; Lee, Jiwoo ; Kwak, Mi Kyung ; Hong, Eun‐Gyoung ; Choi, Yun Mi ; Ha, Yeonjung
Subjects: Adult ; Alcohol ; Body composition ; Body mass index ; cardiovascular disease ; Clinical outcomes ; Diabetes ; fatty liver ; Fibrosis ; Hand Strength ; Hepatitis ; Hospitals ; Humans ; Liver diseases ; metabolic dysfunction ; Metabolic syndrome ; Musculoskeletal system ; Non-alcoholic Fatty Liver Disease - complications ; Non-alcoholic Fatty Liver Disease - epidemiology ; Obesity ; Obesity - complications ; Original ; Overweight ; Patients ; Sarcopenia ; Ultrasonic imaging ; visceral adiposity
Is Part Of: Journal of cachexia, sarcopenia and muscle, 2023-12, Vol.14 (6), p.2747-2756
Description: Background We examined the incidence and predictors of clinical outcomes in metabolic dysfunction‐associated fatty liver disease (MAFLD), focusing on anthropometric parameters. Methods Adult patients with MAFLD were identified in nationwide databases and a hospital cohort. Primary endpoints were atherosclerotic cardiovascular disease (ASCVD) and advanced fibrosis. Logistic and Cox regression analyses were used to analyse the association between anthropometric parameters and endpoints. Results In total, 4407 of 15 256 (28.9%) and 6274 of 25 784 subjects (24.3%) had MAFLD in the nationwide database; of these, 403 (9.2%) and 437 (7.0%) subjects were of lean/normal weight, respectively. Compared to the overweight/obese group, the lean/normal weight group had a significantly lower muscle mass (15.0 vs. 18.9 kg) and handgrip strength (31.9 vs. 35.1 kg) and had a higher ASCVD risk (9.0% vs. 6.3% and 15.9% vs. 8.5%; Ps < 0.001). Sarcopenia (odds ratio [OR], 6.66; 95% confidence interval [CI], 1.79–24.80) and handgrip strength (OR, 0.92; 95% CI, 0.86–0.97; Ps = 0.005) were associated with the ASCVD risk in the lean/normal weight group. In a hospital cohort (n = 1363), the ASCVD risk was significantly higher in the lean/normal weight group than in the overweight/obese group (median follow‐up, 39.1 months). Muscle mass was inversely correlated with the ASCVD risk (hazard ratio [HR], 0.72; 95% CI, 0.56–0.94), while visceral adiposity was associated with advanced fibrosis (HR, 1.36; 95% CI, 1.10–1.69; Ps < 0.05). Conclusions Muscle mass/strength was significantly associated with the ASCVD risk in patients with MAFLD. Visceral adiposity was an independent predictor of advanced fibrosis.
Publisher: Germany: John Wiley & Sons, Inc
Language: English
Identifier: ISSN: 2190-5991
EISSN: 2190-6009
DOI: 10.1002/jcsm.13351
PMID: 37881112
Source: Geneva Foundation Free Medical Journals at publisher websites
MEDLINE
PubMed Central
Wiley Journals Open Access
ProQuest Central
DOAJ Directory of Open Access Journals

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Impact of anthropometric parameters on outcomes in Asians with metabolic dysfunction‐associated fatty liver disease

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