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0024 The Relationship Between Diurnal Variation of Inflammatory Cytokines and Nocturnal Oxygenation Indices in Obstructive Sleep Apnea

Sleep (New York, N.Y.), 2018-04, Vol.41 (suppl_1), p.A10-A10 [Peer Reviewed Journal]

Sleep Research Society 2018. Published by Oxford University Press [on behalf of the Sleep Research Society]. All rights reserved. For permissions, please email: journals.permissions@oup.com 2018 ;Copyright © 2018 Sleep Research Society ;ISSN: 0161-8105 ;EISSN: 1550-9109 ;DOI: 10.1093/sleep/zsy061.023

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  • Title:
    0024 The Relationship Between Diurnal Variation of Inflammatory Cytokines and Nocturnal Oxygenation Indices in Obstructive Sleep Apnea
  • Author: Yang, H ; Sawyer, A M
  • Subjects: Cytokines ; Hypoxia ; Sleep apnea ; Tumor necrosis factor-TNF
  • Is Part Of: Sleep (New York, N.Y.), 2018-04, Vol.41 (suppl_1), p.A10-A10
  • Description: Abstract Introduction Cyclic hypoxia-reoxygenation in obstructive sleep apnea (OSA) induces oxidative stress and systemic inflammation. Hypothesis: Repeated intermittent hypoxia (IH) in OSA is associated with cytokine diurnal variation. Methods A cross-sectional, single-night study of 48 adults undergoing diagnostic polysomnography (PSG; OSA n=25; non-OSA n= 23) with strict inflammatory confounder criteria. PSG-derived variables: apnea-hypopnea index (AHI), mean O2, total sleep time (TST) O2 saturation 80%-90% (OSD80%) and ≤ 88% (TS88%), O2 nadir, arousal index (AI). Cytokine plasma concentrations, interleukin-6 (IL-6), interleukin-8 (IL-8), interleukin-10 (IL-10), and tumor necrosis factor-α (TNF-α), measured by a Luminex Human MMP 5-Plex Panel at pre-sleep bout (8pm; Time 1) and post-sleep bout (6am; Time 2). Cytokine diurnal variation, D=Time 1 - Time 2. Wilcoxon rank-sum test for group differences; scatterplots and Spearman partial rank correlation for cytokine diurnal variation (D) and PSG-derived oxygenation indices association, adjusted for age, body mass index, cardiovascular disease, and type 2 diabetes mellitus. Results Middle-aged (47.8 ± 15.8 yrs), obese (33.5 ± 8.5 kg/m2), men (41.7%) with OSA (AHI, mean 14.3 events/hr) and non-OSA (AHI, mean 1.8 events/hr). Significant group differences identified for OSA-specific PSG indices but not for sleep stage distribution or sleep continuity indices. Significant TNF-α D in both OSA and non-OSA group (p=0.0005; p=0.0023, respectively) but no differences between groups (p=0.66); trend for IL-8 D in only OSA group was identified (p=0.198) but no between-group differences (p=0.156). In OSA group, IL-8 D was positively correlated to OSD80% and TS88% (r=0.448, p=0.0405; r=0.50, p=0.0198, respectively); IL-6 D was positively correlated to O2 nadir and AI (r=0.482, p=0.0257; r=0.497, p=0.0205, respectively). No significant relationships between any cytokine D and PSG-defined oxygenation indices in non-OSA group. Conclusion IH in OSA is associated with IL-6 and IL-8 diurnal variation; IL-8 may be a specific biomarker of IH in OSA and may be causal mechanism of atherosclerosis risk in OSA. Support (If Any) Supported by American Nurses Foundation and Sigma Theta Tau International (Yang, PI) and Penn State University Williamson Endowment Award (Yang, PI).
  • Publisher: US: Oxford University Press
  • Language: English
  • Identifier: ISSN: 0161-8105
    EISSN: 1550-9109
    DOI: 10.1093/sleep/zsy061.023
  • Source: ProQuest One Psychology
    AUTh Library subscriptions: ProQuest Central
    Alma/SFX Local Collection
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