Language:

Macrophage signaling in HIV-1 infection

Retrovirology, 2010-04, Vol.7 (1), p.34-34, Article 34 [Peer Reviewed Journal]

COPYRIGHT 2010 BioMed Central Ltd. ;2010 Herbein et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. ;Distributed under a Creative Commons Attribution 4.0 International License ;Copyright ©2010 Herbein et al; licensee BioMed Central Ltd. 2010 Herbein et al; licensee BioMed Central Ltd. ;ISSN: 1742-4690 ;EISSN: 1742-4690 ;DOI: 10.1186/1742-4690-7-34 ;PMID: 20380698

Full text available

Citations Cited by

Actions
1. Add to My Research
2. Remove from My Research
3. E-mail
4. Print
5. Permalink
6. Citation
7. EasyBib
8. EndNote
9. RefWorks
10. Delicious
11. Export RIS
12. Export BibTeX

Title:
Macrophage signaling in HIV-1 infection
Author: Herbein, Georges ; Gras, Gabriel ; Khan, Kashif Aziz ; Abbas, Wasim
Subjects: Acquired immune deficiency syndrome ; AIDS ; Apoptosis ; Binding sites ; Cellular signal transduction ; Chemokines ; Disease ; Genetic aspects ; Genetic transcription ; Health aspects ; HIV ; HIV Envelope Protein gp120 ; HIV Envelope Protein gp120 - immunology ; HIV Envelope Protein gp120 - physiology ; HIV infection ; HIV Infections ; HIV Infections - immunology ; HIV Infections - virology ; HIV-1 ; HIV-1 - immunology ; HIV-1 - pathogenicity ; Human health and pathology ; Human immunodeficiency virus ; Humans ; Immune system ; Infectious diseases ; Life Sciences ; Lymphocytes ; Macrophage Activation ; Macrophages ; Macrophages - immunology ; nef Gene Products, Human Immunodeficiency Virus ; nef Gene Products, Human Immunodeficiency Virus - immunology ; nef Gene Products, Human Immunodeficiency Virus - physiology ; Pathogenesis ; Phosphorylation ; Proteins ; Review ; Risk factors ; Signal Transduction ; tat Gene Products, Human Immunodeficiency Virus ; tat Gene Products, Human Immunodeficiency Virus - immunology ; tat Gene Products, Human Immunodeficiency Virus - physiology ; Viral proteins ; Virulence Factors ; Virulence Factors - immunology ; Virulence Factors - physiology ; vpr Gene Products, Human Immunodeficiency Virus ; vpr Gene Products, Human Immunodeficiency Virus - immunology ; vpr Gene Products, Human Immunodeficiency Virus - physiology
Is Part Of: Retrovirology, 2010-04, Vol.7 (1), p.34-34, Article 34
Description: The human immunodeficiency virus-1 (HIV-1) is a member of the lentivirus genus. The virus does not rely exclusively on the host cell machinery, but also on viral proteins that act as molecular switches during the viral life cycle which play significant functions in viral pathogenesis, notably by modulating cell signaling. The role of HIV-1 proteins (Nef, Tat, Vpr, and gp120) in modulating macrophage signaling has been recently unveiled. Accessory, regulatory, and structural HIV-1 proteins interact with signaling pathways in infected macrophages. In addition, exogenous Nef, Tat, Vpr, and gp120 proteins have been detected in the serum of HIV-1 infected patients. Possibly, these proteins are released by infected/apoptotic cells. Exogenous accessory regulatory HIV-1 proteins are able to enter macrophages and modulate cellular machineries including those that affect viral transcription. Furthermore HIV-1 proteins, e.g., gp120, may exert their effects by interacting with cell surface membrane receptors, especially chemokine co-receptors. By activating the signaling pathways such as NF-kappaB, MAP kinase (MAPK) and JAK/STAT, HIV-1 proteins promote viral replication by stimulating transcription from the long terminal repeat (LTR) in infected macrophages; they are also involved in macrophage-mediated bystander T cell apoptosis. The role of HIV-1 proteins in the modulation of macrophage signaling will be discussed in regard to the formation of viral reservoirs and macrophage-mediated T cell apoptosis during HIV-1 infection.
Publisher: England: BioMed Central Ltd
Language: English
Identifier: ISSN: 1742-4690
EISSN: 1742-4690
DOI: 10.1186/1742-4690-7-34
PMID: 20380698
Source: Hyper Article en Ligne (HAL) (Open Access)
GFMER Free Medical Journals
MEDLINE
PubMed Central
Springer Open Access Journals
ROAD: Directory of Open Access Scholarly Resources
ProQuest Central
DOAJ Directory of Open Access Journals

Back to results list


INSPIRE LIBRARY - TON DUC THANG UNIVERSITY	(84-028) 37 755 057	Feedback
19 Nguyen Huu Tho St. Dist.7, HCM	thuvien@tdtu.edu.vn	Feedback

Macrophage signaling in HIV-1 infection

Searching Remote Databases, Please Wait